1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Picrotoxin

Picrotoxin (Synonyms: Cocculin)

Cat. No.: HY-101391 Purity: >98.0%
Handling Instructions

Picrotoxin (Cocculin) is a natural noncompetitive antagonist of GABAA receptor, binds to the interface pocket on the GABAR. Picrotoxin (Cocculin) induces convulsions.

For research use only. We do not sell to patients.

Picrotoxin Chemical Structure

Picrotoxin Chemical Structure

CAS No. : 124-87-8

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Description

Picrotoxin (Cocculin) is a natural noncompetitive antagonist of GABAA receptor, binds to the interface pocket on the GABAR[1][2]. Picrotoxin (Cocculin) induces convulsions[2].

In Vivo

Picrotoxin (1.0 mg/kg, i.p. once a day for 5 days) acts as a GABAA receptor antagonist, and increased the number of ligodendrocyte progenitor cells (OPCs) pairs in NG2-CreERTM:EYFP mice[1].

Animal Model: NG2-CreERTM:EYFP mice[1]
Dosage: 1.0 mg/kg
Administration: I.P. once a day for 5 days
Result: Increased the number of ligodendrocyte progenitor cells pairs.
Molecular Weight

301.29

Formula

C₁₅H₁₈O₇ . C₁₅H₁₆O₆

CAS No.

124-87-8

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (99.57 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3191 mL 16.5953 mL 33.1906 mL
5 mM 0.6638 mL 3.3191 mL 6.6381 mL
10 mM 0.3319 mL 1.6595 mL 3.3191 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.30 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.30 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.30 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Picrotoxin
Cat. No.:
HY-101391
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