2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Anisatin

Anisatin, a pure toxic substance isolated from the seeds of a Japanese plant (Illicium anisatum) acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC50 of ~1.10 μM.

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Anisatin Chemical Structure

Anisatin Chemical Structure

CAS No. : 5230-87-5

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Based on 1 publication(s) in Google Scholar

Anisatin Related Antibodies

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Description

Anisatin, a pure toxic substance isolated from the seeds of a Japanese plant (Illicium anisatum) acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC50 of ~1.10 μM[1].

In Vitro

Anisatin inhibits [3H]diazepam binding enhanced by either GABA or pentobarbital, without affecting the basal specific binding to rat brain membranes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anisatin Related Antibodies
In Vivo

In mice, the LD50 reported for anisatin ranges from 0.76 to 1 mg/kg (po and ip)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

328.31

Formula

C15H20O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@]12[C@]3([C@@H](C[C@H]2O)C)C[C@@H](OC([C@@H]3O)=O)[C@](O)([C@]14C(OC4)=O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥98.0%

COA (264 KB)

Handling Instructions (2659 KB)
References
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Anisatin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anisatin5230-87-5GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorpicrotoxindorsalrootganglionpatchclampsingle channelInhibitorinhibitorinhibit

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