CHF-2993
CHF-2993 is an orally active anticonvulsant. CHF-2993 antagonizes Bicuculline (HY-N0219)- and Picrotoxin (HY-101391)-induced tonic convulsions in mice, shows no activity against Pentylenetetrazole-induced clonic convulsions in mice, and partially reduces Veratridine (HY-N6691)-induced aspartate efflux in rat cortical synaptosomes. CHF-2993 can be used in the research of epilepsy.
For research use only. We do not sell to patients.
- CAS No.: 202914-21-4
- Formula: C12H16N2O2
- Molecular Weight:220.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
CHF-2993 (multiple administrations; oral administration) antagonizes bicuculline-induced tonic seizures in male CD-1 mice, with an oral ED50 of 65 mg/kg[1].
CHF-2993 (multiple administrations; oral administration) exerts a protective effect against picrotoxin-induced tonic convulsions in male CD-1 mice, with an oral ED50 of 14 mg/kg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 202914-21-4
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Molecular Weight 220.27
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Formula C12H16N2O2
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SMILES
N([C@H](C(N)=O)CO)C1CC=2C(C1)=CC=CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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