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Art. -Nr.: HY-118018

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CHF-2993

CHF-2993 is an orally active anticonvulsant. CHF-2993 antagonizes Bicuculline (HY-N0219)- and Picrotoxin (HY-101391)-induced tonic convulsions in mice, shows no activity against Pentylenetetrazole-induced clonic convulsions in mice, and partially reduces Veratridine (HY-N6691)-induced aspartate efflux in rat cortical synaptosomes. CHF-2993 can be used in the research of epilepsy.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 202914-21-4
Formel: C₁₂H₁₆N₂O₂
Molecular Weight:220.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

CHF-2993 Chemical Structure

CAS. Nr.: 202914-21-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Biologische Aktivität

Beschreibung

In Vivo

CHF-2993 (Compound 49) (multiple administrations; oral administration) exhibits anticonvulsant activity against maximal electroshock-induced tonic seizures in male CD-1 mice, with an oral ED₅₀ of 36 mg/kg and low neurotoxicity (TD₅₀ = 1172 mg/kg)^[1].
CHF-2993 (multiple administrations; oral administration) antagonizes bicuculline-induced tonic seizures in male CD-1 mice, with an oral ED₅₀ of 65 mg/kg^[1].
CHF-2993 (multiple administrations; oral administration) exerts a protective effect against picrotoxin-induced tonic convulsions in male CD-1 mice, with an oral ED₅₀ of 14 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 202914-21-4
Molecular Weight 220.27
Formel C₁₂H₁₆N₂O₂
SMILES

N([C@H](C(N)=O)CO)C1CC=2C(C1)=CC=CC2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Ghidini E, et al. Synthesis and anticonvulsant activity of a class of 2-amino 3-hydroxypropanamide and 2-aminoacetamide derivatives. Bioorg Med Chem. 2006;14(10):3263-3274. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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