98394-38-8
Chemical Structure
γ-Kainylglutamic acid
Synonym(s): γ-Kainic acid-glutamic acid
- CAS No.: 98394-38-8
- Formula:C15H22N2O7
- Molecular Weight:342.34
IUPAC Name: (2-((2S,3S,4S)-2-carboxy-4-(prop-1-en-2-yl)pyrrolidin-3-yl)acetyl)-L-glutamic acid
InChIKey: KRCXEEUOPUTIDN-WJZNIJOASA-N
SMILES: OC(CC[C@@H](C(O)=O)NC(C[C@H]1[C@H](CN[C@@H]1C(O)=O)C(C)=C)=O)=O
Biological Activity: γ-Kainylglutamic acid (γ-Kainic acid-glutamic acid), a dipeptide derived from kainic and L-Glutamic acids, is a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties. γ-Kainylglutamic acid inhibits the stimulation of Na+ fluxes induced in brain slices by the neuroexcitant N-methyl-D-aspartic acid. γ-Kainylglutamic acid is also effective in protecting mice from picrotoxin-induced convulsions with an EC50 value of 0.17 μmol[1].
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γ-Kainylglutamic acid | γ-Kainylglutamic acid (γ-Kainic acid-glutamic acid), a dipeptide derived from kainic and L-Glutamic acids, is a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties. γ-Kainylglutamic acid inhibits the stimulation of Na+ fluxes induced in brain slices by the neuroexcitant N-methyl-D-aspartic acid. γ-Kainylglutamic acid is also effective in protecting mice from picrotoxin-induced convulsions with an EC50 value of 0.17 μmol. | |||||||||||||||||||||
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