21416-53-5
Chemical Structure
Picrotin
- CAS No.: 21416-53-5
- Formula:C15H18O7
- Molecular Weight:310.30
IUPAC Name: (1aR,2aR,2a1R,3S,6R,6aS,8aS,9S)-2a-hydroxy-9-(2-hydroxypropan-2-yl)-2a1-methylhexahydro-8H-1,5,7-trioxa-3,6-methanocyclopenta[ij]cyclopropa[a]azulene-4,8(2a1H)-dione
InChIKey: RYEFFICCPKWYML-QCGISDTRSA-N
SMILES: C[C@]([C@@](C1)([C@]2([H])[C@@](C(O)(C)C)([H])[C@@]3([H])OC2=O)O)([C@]3([H])OC4=O)[C@@]54[C@@H]1O5
Biological Activity: Picrotin is an active compound, also is one of the composition of picrotoxin (an antagonist of GABAA receptors (GABAARs) and glycine receptors (GlyRs)). Picrotin has sensitivity for GlyRs with IC50 values range from 5.2 μM to 106 μM. Picrotin can be used for the research of neurotransmission[1][2].
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Picrotin | 99.95% | Picrotin is an active compound, also is one of the composition of picrotoxin (an antagonist of GABAA receptors (GABAARs) and glycine receptors (GlyRs)). Picrotin has sensitivity for GlyRs with IC50 values range from 5.2 μM to 106 μM. Picrotin can be used for the research of neurotransmission. | ||||||||||||||||||||
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Picrotin (Standard) | ≥98% | Picrotin (Standard) is the analytical standard of Picrotin. This product is intended for research and analytical applications. Picrotin is an active compound, also is one of the composition of picrotoxin (an antagonist of GABAA receptors (GABAARs) and glycine receptors (GlyRs)). Picrotin has sensitivity for GlyRs with IC50 values range from 5.2 μM to 106 μM. Picrotin can be used for the research of neurotransmission. | ||||||||||||||||||||
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- [1]. Yang Z, et al. A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem. 2007 Oct;103(2):580-9. [Content Brief]
- [2]. Dian-Shi Wang, et al. Mechanisms for picrotoxinin and picrotin blocks of alpha2 homomeric glycine receptors. J Biol Chem. 2007 Jun 1;282(22):16016-35. [Content Brief]
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