59556-18-2
59556-18-2
Chemical Structure
Gabaculine
- CAS No.: 59556-18-2
- Formula:C7H9NO2
- Molecular Weight:139.15
InChIKey: KFNRJXCQEJIBER-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC(C1)N)O
Biological Activity: Gabaculine is an amino acid neurotoxin and blood-brain barrier-permeable GABA transaminase inhibitor, with an IC50 of 1 μM in beef and Pseudomonas ovalis. Gabaculine elevates endogenous synaptic and brain GABA levels and enhances GABA activity. Gabaculine induces sedation, hypothermia, loss of righting reflex, and prevents convulsions in mice. Gabaculine is applicable to research related to neurological disorders[1][2][3].
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Gabaculine | Gabaculine is an amino acid neurotoxin and blood-brain barrier-permeable GABA transaminase inhibitor, with an IC50 of 1 μM in beef and Pseudomonas ovalis. Gabaculine elevates endogenous synaptic and brain GABA levels and enhances GABA activity. Gabaculine induces sedation, hypothermia, loss of righting reflex, and prevents convulsions in mice. Gabaculine is applicable to research related to neurological disorders. | |||||||||||||||||||||
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References
- [1]. Rando R R, et al. The in vivo inhibition of GABA-transaminase by gabaculine. Biochemical and Biophysical Research Communications, 1977, 76(4): 1276-1281.
- [2]. Matsui Y, et al. Effects of gabaculine, a new potent inhibitor of gamma-aminobutyrate transaminase, on the brain gamma-aminobutyrate content and convulsions in mice. Life Sciences, 1977, 20(7): 1291-1295.
- [3]. Ogawa Y, et al. The indirect γ-aminobutyric acid (GABA) receptor agonist gabaculine-induced loss of the righting reflex may inhibit the descending analgesic pathway. Pharmacol Biochem Behav. 2020;198:173034. [Content Brief]
Keywords
