Others (その他)

Boc-protected photo-Leu(tBu) (compound 4) is a synthetic intermediate of diazirine-containing probe (photo-Met).

Cylic-DAP is a substrate of splenic cyclic phosphodiesterases.

Cyclic-di-DAP is a base-modified analog of c-di-AMP (HY-12326).

SIK1-IN-1 (Compound 27) is a selective Salt-inducible kinase 1 (SIK1) inhibitor with an IC₅₀ of 0.7  nM for SIK1 over SIK2 and SIK3. SIK1-IN-1 has no cytotoxicity against HEK293 cells and PBMCs (maximum concentration of 30 μM). SIK1-IN-1 also has potent inhibitory activities for 392 kinases, in particular tyrosine kinases, such as FGR, HCK and LYN).

HPPD/PPO-IN-1 (Compound B14) is dual-functional inhibitor of HPPD and PPO with IC₅₀s of 0.12  μM and 0.51 μM for Arabidopsis thaliana HPPD and Nicotiana tabacum PPO, respectively. HPPD/PPO-IN-1 has broad-spectrum herbicidal activity against weeds with a crop safety to peanuts and cotton. HPPD/PPO-IN-1 can be used for the development of environmentally friendly herbicides.

BRD4 ligand 13 is a BRD4 ligand that can be used for the synthesis of PROTACs, such as Cath-L-dBET1 (HY-173257). BRD4 ligand 13 is a target protein ligand-conjugate that can be used for the synthesis of PROTACs, such as SJH1-51B (HY-162240).

PPO-IN-21 (Compound A20) is a protoporphyrinogen IX oxidase (PPO) inhibitor with a K_i of 15.2 nM for Nicotiana tabacum PPO. PPO-IN-21 has inhibitory activity against various weeds (including monocots and dicots). PPO-IN-21 can be used as herbicide.

PPO-IN-22 (Compound B-04) is a benzothiazol-2(3H)-one derivative. PPO-IN-22 is a herbicide. PPO-IN-22 exhibits excellent post-emergence herbicidal activity against broadleaf weeds. PPO-IN-22 demonstrates potent pre-emergence activity against both dicotyledonous and monocotyledonous weeds. PPO-IN-22 exhibits favorable crop safety as a selective pre-emergence herbicide in soybean, peanut, and cotton cultivation systems.

JAX-44 is a potent root architecture modulator. JAX-44 maintains primary root length while substantially increasing lateral root numbers, thereby optimizing the plant’s overall root system. JAX-44 is the metabolic precursor of JAX-77 (HY-178359) and can be converted to Indole-3-butyric acid (IBA) (HY-N0186). JAX-44 can be used for auxin biology and root development research.

JAX-77 is a potent root architecture modulator. JAX-77 maintains primary root length while substantially increasing lateral root numbers, thereby optimizing the plant’s overall root system. JAX-77 is the key intermediate metabolite formed from the hydrolysis of JAX-44 (HY-178358) and can be converted to Indole-3-butyric acid (IBA) (HY-N0186). JAX-77 can be used for auxin biology and root development research.

(Rac)-IDO1-IN-30 is the Rac isomer of IDO1-IN-30 (HY-178479). IDO1-IN-30 is a potent and highly selective IDO1 inhibitor. IDO1-IN-30 has an IC₅₀ of 4.8 nM to IDO1 in SKOV3 cells. IDO1-IN-30 does not show significant cytotoxicity at 25 µM in HepG2 cells. IDO1-IN-30 can eliminate inhibition of CYP450 enzymes (such as 3A4, 2C9, 2D6). IDO1-IN-30 can be used for research on cancer and inflammatory conditions.

3'-ONH2-dATP is a 3'-O-blocked reversible terminator deoxynucleotide triphosphate. 3'-ONH2-dATP stops DNA polymerization after single-nucleotide addition to an initiator strand, and its 3'-ONH2 blocking group can be removed to restore a free 3'-OH for subsequent extension.

Im-m7GDP is the cap reagent that can be used for nucleic acid synthesis.

10-Iododecan-1-ol is a biochemical reagent.

ML301 is a small molecule G-protein agonist. ML301 can be inhibited by SR142948A with an IC₅₀ of around 63 nM. ML301 fully competes for ¹²⁵I-NT binding.

(α-D-Mannopyranosyloxy)3-N3 is a type of N-acetylgalactosamine (GalNAc) that exhibits liver-targeting properties and can be used in the synthesis of oligonucleotides.

Desferrioxamine X3 is an agent that binds iron and aluminium.

Desferrioxamine T1 is an agent that binds iron and aluminium.

PPO-IN-23 is a potent protoporphyrinogen IX oxidase (PPO) inhibitor with a K_i of 12.4 nM. PPO-IN-23 forms two hydrogen bonds with the Arg98 residue of Nicotiana tabacum PPO (NtPPO). PPO-IN-23 exhibits potent herbicidal activity and good crop safety. PPO-IN-23 can be used for weeds management.

HPPD-IN-7 (Compound 35) is an Arabidopsis thaliana HPPD inhibitor (IC₅₀ of 89 nM) and herbicide. HPPD-IN-7 exhibits herbicidal activity against Digitaria sanguinalis, Amaranthus retroflexus, Chenopodium serotinum, Abutilon theophrasti, Setaria viridis.