1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. SHP394

SHP394 

Cat. No.: HY-114397 Purity: 99.41%
Handling Instructions

SHP394 is an orally active, selective and allosteric inhibitor of SHP2, with an IC50 of 23 nM.

For research use only. We do not sell to patients.

SHP394 Chemical Structure

SHP394 Chemical Structure

CAS No. : 2055757-40-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 715 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 715 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

SHP394 is an orally active, selective and allosteric inhibitor of SHP2, with an IC50 of 23 nM[1].

IC50 & Target

IC50: 23 nM (SHP2)[1]

In Vitro

SHP394 inhibits Caco-2 cells proliferation with the IC50 of 297 nM[1].
SHP394 exhibits antiproliferation activity against the Detroit-562 pharyngeal carcinoma cell line in vitro (IC50= 1.38 μM) [1].
SHP394 decreases p-ERK with an IC50 of 18 nM KYSE520 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SHP394 (20-80 mg/kg; oral gavage; twice daily) dose-dependent reduces tumor volume[1].
SHP394 (80 mg/kg; oral gavage; twice daily) causes tumor 34% regression and reduces mouse host bodyweight after dosing for 14 days[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week old female athymic NU/NU mice were inoculated subcutaneously with Detroit-562 pharyngeal carcinoma cells[1].
Dosage: 20, 40, and 80 mg/kg
Administration: Oral gavage; twice daily
Result: Demonstrated a clear dose-dependent reduction in tumor volume.
Molecular Weight

470.51

Formula

C₂₀H₂₅F₃N₆O₂S

CAS No.
SMILES

NC1=C(C(N(C)C(N2CCC3(CO[[email protected]@H](C)[[email protected]]3N)CC2)=N1)=O)SC4=C(C(F)(F)F)N=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (531.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1254 mL 10.6268 mL 21.2535 mL
5 mM 0.4251 mL 2.1254 mL 4.2507 mL
10 mM 0.2125 mL 1.0627 mL 2.1254 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (13.28 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (13.28 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (13.28 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SHP394SHP 394SHP-394PhosphataseallostericSHP2Caco-2Detroit-562pharyngealcarcinomap-ERKKYSE520Inhibitorinhibitorinhibit

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Product Name:
SHP394
Cat. No.:
HY-114397
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