1. Cell Cycle/DNA Damage
  2. SRPK
  3. SRPKIN-1

SRPKIN-1 

Cat. No.: HY-116856
Handling Instructions

SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect.

For research use only. We do not sell to patients.

SRPKIN-1 Chemical Structure

SRPKIN-1 Chemical Structure

CAS No. : 2089226-94-6

Size Stock
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect[1].

IC50 & Target

IC50: 35.6 nM (SRPK1), 98 nM (SRPK2)[1]

In Vitro

SRPKIN-1 treatment at 200 nM (10, 50, 100, 200 nM, 16 hours) significantly reduces SR protein phosphorylation at the steady state with or without washout[1].

SRPK-IN-1 potently converts VEGF from pro-angiogenic to anti-angiogenic isoform[1].

Cell Viability Assay[1]

Cell Line: Ba/F3 cells
Concentration: 0-10000 nM
Incubation Time: 72 h
Result: Potently decreased the level of SR phosphorylation in a dose-dependent manner, leading to increased VEGF-A165b RNA as well as protein even at a dose of 200 nM[1].
In Vivo

SRPKIN-1 (50 nM, 300 nM,1 μL, 5 times) blocks angiogenesis in a CNV mouse model through VEGF alternative splicing[1].

Animal Model: Mice[1]
Dosage: 50 nM, 300 nM, 1 μL
Administration: Intravitreal injection, 5 times
Result: SRPKIN-1-treated mice is significantly suppressed in a dose-dependent manner based upon measurement of the CNV area[1].
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

472.53

Formula

C₂₇H₂₁FN₂O₃S

CAS No.

2089226-94-6

SMILES

O=S(C1=CC=CC(C2=C(CC)C=C3C(C(C)(C)C(NC4=C5C=CC(C#N)=C4)=C5C3=O)=C2)=C1)(F)=O

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SRPKIN-1
Cat. No.:
HY-116856
Quantity:

SRPKIN-1

Cat. No.: HY-116856