1. Cell Cycle/DNA Damage
  2. SRPK
  3. SRPKIN-1


Cat. No.: HY-116856
Handling Instructions

SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect.

For research use only. We do not sell to patients.

SRPKIN-1 Chemical Structure

SRPKIN-1 Chemical Structure

CAS No. : 2089226-94-6

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SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect[1].

IC50 & Target

IC50: 35.6 nM (SRPK1), 98 nM (SRPK2)[1]

In Vitro

SRPKIN-1 treatment at 200 nM (10, 50, 100, 200 nM, 16 hours) significantly reduces SR protein phosphorylation at the steady state with or without washout[1].

SRPK-IN-1 potently converts VEGF from pro-angiogenic to anti-angiogenic isoform[1].

Cell Viability Assay[1]

Cell Line: Ba/F3 cells
Concentration: 0-10000 nM
Incubation Time: 72 h
Result: Potently decreased the level of SR phosphorylation in a dose-dependent manner, leading to increased VEGF-A165b RNA as well as protein even at a dose of 200 nM[1].
In Vivo

SRPKIN-1 (50 nM, 300 nM,1 μL, 5 times) blocks angiogenesis in a CNV mouse model through VEGF alternative splicing[1].

Animal Model: Mice[1]
Dosage: 50 nM, 300 nM, 1 μL
Administration: Intravitreal injection, 5 times
Result: SRPKIN-1-treated mice is significantly suppressed in a dose-dependent manner based upon measurement of the CNV area[1].
Molecular Weight









Room temperature in continental US; may vary elsewhere


Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 115 mg/mL (243.37 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1163 mL 10.5813 mL 21.1627 mL
5 mM 0.4233 mL 2.1163 mL 4.2325 mL
10 mM 0.2116 mL 1.0581 mL 2.1163 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5.75 mg/mL (12.17 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5.75 mg/mL (12.17 mM); Clear solution

*All of the co-solvents are provided by MCE.
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