1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
  2. PKA

Synaptamide (Synonyms: Dehydroepiandrosteron(DHEA); Docosahexaenoyl ethanolamide)

Cat. No.: HY-100197 Purity: >98.0%
Handling Instructions

Synaptamide is a potent mediator for neurogenic differentiation of NSCs acting through PKA/CREB activation.

For research use only. We do not sell to patients.

Synaptamide Chemical Structure

Synaptamide Chemical Structure

CAS No. : 162758-94-3

Size Price Stock Quantity
67 mM * 200 uL in Ethanol USD 72 In-stock
Estimated Time of Arrival: December 31
67 mM * 400 uL in Ethanol USD 114 In-stock
Estimated Time of Arrival: December 31
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5 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation


Synaptamide is a potent mediator for neurogenic differentiation of NSCs acting through PKA/CREB activation. Target: in vitro: Synaptamide inhibits forskolin-mediated cAMP production (IC50 =6 μM) in CHO-HCR cells. Synaptamide decreases the viability of the LNCaP and PC3 prostate cancer cell lines (IC50=120-130 μM) grown in media containing 10% fetal bovine serum. [1] Synaptamide is an endogenous DHA metabolite with endocannabinoid-like structure, promotes neurite growth, synaptogenesis and synaptic function. Synaptamide potently induces neuronal differentiation of NSCs. Treatment of NSCs with Synaptamide at low nanomolar concentrations significantly increased the number of MAP2 and Tuj-1 positive neurons with concomitant induction of PKA/CREB phosphorylation. [2]

Solvent & Solubility
In Vitro: 

Ethanol : 25 mg/mL (67.28 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6914 mL 13.4568 mL 26.9136 mL
5 mM 0.5383 mL 2.6914 mL 5.3827 mL
10 mM 0.2691 mL 1.3457 mL 2.6914 mL
*Please refer to the solubility information to select the appropriate solvent.
Molecular Weight








Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Cat. No.: HY-100197