1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
  2. PKA

Synaptamide (Synonyms: Docosahexaenoyl ethanolamide)

Cat. No.: HY-100197
Handling Instructions

Synaptamide is a potent mediator for neurogenic differentiation of NSCs acting through PKA/CREB activation.

For research use only. We do not sell to patients.
Synaptamide Chemical Structure

Synaptamide Chemical Structure

CAS No. : 162758-94-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO $66 In-stock
5 mg $60 In-stock
10 mg $95 In-stock
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

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  • Technical Information

  • References

Description

Synaptamide is a potent mediator for neurogenic differentiation of NSCs acting through PKA/CREB activation. Target: in vitro: Synaptamide inhibits forskolin-mediated cAMP production (IC50 =6 μM) in CHO-HCR cells. Synaptamide decreases the viability of the LNCaP and PC3 prostate cancer cell lines (IC50=120-130 μM) grown in media containing 10% fetal bovine serum. [1] Synaptamide is an endogenous DHA metabolite with endocannabinoid-like structure, promotes neurite growth, synaptogenesis and synaptic function. Synaptamide potently induces neuronal differentiation of NSCs. Treatment of NSCs with Synaptamide at low nanomolar concentrations significantly increased the number of MAP2 and Tuj-1 positive neurons with concomitant induction of PKA/CREB phosphorylation. [2]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.6914 mL 13.4568 mL 26.9136 mL
5 mM 0.5383 mL 2.6914 mL 5.3827 mL
10 mM 0.2691 mL 1.3457 mL 2.6914 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

371.56

Formula

C₂₄H₃₇NO₂

CAS No.

162758-94-3

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO; Ethanol: 25 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Synaptamide
Cat. No.:
HY-100197
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