Acyltransferase
Diacylglycerol acyltransferase; Diglyceride acyltransferase; acyl-CoA:cholesterol acyltransferase; mono- acylglycerol acyltransferase
Acyltransferase (AT) catalyzes the transfer of an acyl moiety from acyl-coenzyme A (acyl-CoA) to an acceptor. Acyltransferases play important roles in the maintenance of homeostasis in the human body and have been linked to various diseases. The Acyltransferase family includes acyl-CoA:cholesterol AT (ACAT), diacylglycerol AT (DGAT), and monoacylglycerol AT (MGAT) for the metabolism of lipids.
ACAT (acyl-coenzyme A:cholesterol acyltransferase) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and fatty acyl-coenzyme A. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles in cellular cholesterol homeostasis in various tissues.
DGAT (acyl-CoA:diacylglycerol acyltransferase) is an integral membrane enzyme that catalyses the last step of triacylglycerol synthesis from diacylglycerol and acyl-CoA. DGAT activity resides mainly in two distinct membrane bound polypeptides, known as DGAT1 and DGAT2.
MGAT (acyl-CoA:monoacylglycerol acyltransferase) catalyzes the synthesis of diacylglycerol, the precursor of physiologically important lipids such as triacylglycerol and phospholipids. In the intestine, MGAT plays a major role in the absorption of dietary fat because resynthesis of triacylglycerol is required for the assembly of lipoproteins that transport absorbed fat to other tissues.
Acyltransferase Isoform Specific Products
All Product Categories
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Acyltransferase Related Products (243)
Related Products (243)
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Antibodies (4)
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Acyltransferase Isoform Comparison
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CP-113818 (Standard)
0 ImagesCat. No.: HY-105445RCAS No.: 135025-12-6
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Avasimibe (Standard)
0 ImagesSynonyms: CI-1011 (Standard); PD-148515 (Standard)Avasimibe (Standard) is the analytical standard of Avasimibe. This product is intended for research and analytical applications. Avasimibe (CI-1011; PD-148515) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC50s of 24 and 9.2 µM for ACAT1 and ACAT2, respectively. Avasimibe can be used for the research of prostate cancer.
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RP 73163 Racemate
0 ImagesCat. No.: HY-100288CAS No.: 136609-53-5RP 73163 Racemate is the racemate of RP 73163. RP 73163 is a potent ACAT inhibitor, with cholesterol lowering activity.
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2-Furoic acid (Standard)
0 ImagesSynonyms: Pyromucic acid (Standard)2-Furoic acid (Standard) is the analytical standard of 2-Furoic acid. This product is intended for research and analytical applications. 2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation. 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats.
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K-604 dihydrochloride (Standard)
0 ImagesK-604 (dihydrochloride) (Standard) is the analytical standard of K-604 (dihydrochloride). This product is intended for research and analytical applications. K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45±0.06 μM.
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FR186054
0 ImagesCat. No.: HY-117466CAS No.: 179053-90-8FR186054 is an oral active acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor with the IC50 of 99 nM. FR186054 shows hypocholesterolemic effect and can be used for study of hypercholesterolemia and atherosclerosis.
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Purpactin B
0 ImagesCat. No.: HY-N14648CAS No.: 133806-60-7Purpactin B is a cholesterol acyltransferase (ACAT) inhibitor.
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Glisoprenin E
0 ImagesCat. No.: HY-N14816CAS No.: 205594-90-7Glisoprenin E is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea.
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1-Stearoyl-sn-glycerol 3-phosphate sodium
0 ImagesCat. No.: HY-W339834CAS No.: 325465-92-71-Stearoyl-sn-glycerol 3-phosphate sodium is a bioactive phospholipid that plays a crucial role in modulating cellular processes such as motility, proliferation, invasion, survival, and growth factor production, primarily through its interaction with G protein-coupled receptors (GPCRs). Typically found at low concentrations in plasma (~100nM), this compound is synthesized during the formation of membrane phospholipids and is derived from various cell types, including activated platelets, epithelial cells, leukocytes, neuronal cells, and tumor cells. Its unique structure includes stearic acid at the sn-1 position alongside a hydroxyl group at the sn-2 position.
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Cs-2d
0 ImagesCat. No.: HY-175198CAS No.: 2928129-57-9Cs-2d is a selective ceramide synthases Cer1 inhibitor. Cs-2d has potent inhibitory activity toward C. neoformans Cer1, while maintaining a low off-target effect on human hCerS1. Cs-2d has potent antifungal activity with the significant growth inhibition. Cs-2d can be used for invasive fungal infections research.
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GOAT-IN-1 (Standard)
0 ImagesCat. No.: HY-103479RCAS No.: 1452473-54-9GOAT-IN-1 (Standard) is the analytical standard of GOAT-IN-1 (HY-103479). This product is intended for research and analytical applications. GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors.
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LDL-IN-4
0 ImagesLDL-IN-4 (Compound 2) inhibits human acyl-CoA:cholesterol acyltransferase-1 and -2 activities. LDL-IN-4 inhibits copper-mediated low density lipoprotein (LDL) oxidation, with an IC50 of 3 μM. LDL-IN-4 has anti-atherosclerotic biological activity.
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Avasimibe sodium
0 ImagesCat. No.: HY-13215ACAS No.: 166518-61-2Synonyms: CI-1011 sodium; PD-148515 sodiumAvasimibe sodium (CI-1011 sodium; PD-148515 sodium) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC50s of 24 and 9.2 µM for ACAT1 and ACAT2, respectively. Avasimibe sodium can be used for the research of prostate cancer.
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IWP-12 (Standard)
0 ImagesCat. No.: HY-107570RCAS No.: 688353-45-9
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KY-455
0 ImagesCat. No.: HY-167664CAS No.: 178469-71-1KY-455 is a novel inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). KY-455 inhibita rabbit intestinal, hepatic, macrophage and adrenal ACAT with IC50 values of 0.4, 0.9, 2.9 and 4.1 μmol/L, respectively.
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Helminthosporol
0 ImagesHelminthosporol is a natural plant growth-regulator that can promote the growth of rice and lettuce seedlings. Helminthosporol can also inhibit the activity of acyl-CoA: cholesterol acyltransferase (ACAT) in rat liver microsomes and the synthesis of cholesterol esters in macrophages.
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Pradigastat (Standard)
0 ImagesCat. No.: HY-16278RCAS No.: 956136-95-1Synonyms: LCQ-908 (Standard)Pradigastat (Standard) is the analytical standard of Pradigastat. This product is intended for research and analytical applications. Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC50 at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC50 of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro.
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Roselipin 2B
0 ImagesCat. No.: HY-N14578CAS No.: 232258-27-4Roselipin 2B inhibits diacylglycerol acyltransferases (DGAT) of rat hepatic microcosm.
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Cholestanol stearate
0 ImagesCat. No.: HY-186296CAS No.: 59000-66-7Cholestanol stearate serves as a substrate for plasma lecithin:cholesterol acyltransferase (LCAT), with an esterification rate of approximately 70% that of cholesterol. Cholestanol stearate contains both hydrophilic and lipophilic groups, and its components are related to the structural substances of natural products. Cholestanol stearate can be used in studies related to cerebrotendinous xanthomatosis and familial lecithin:cholesterol acyltransferase deficiency.
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Purpactin C
0 ImagesCat. No.: HY-N14649CAS No.: 133806-61-8Purpactin C is a cholesterol acyltransferase (ACAT) inhibitor.
