Acyltransferase
Diacylglycerol acyltransferase; Diglyceride acyltransferase; acyl-CoA:cholesterol acyltransferase; mono- acylglycerol acyltransferase
Acyltransferase (AT) catalyzes the transfer of an acyl moiety from acyl-coenzyme A (acyl-CoA) to an acceptor. Acyltransferases play important roles in the maintenance of homeostasis in the human body and have been linked to various diseases. The Acyltransferase family includes acyl-CoA:cholesterol AT (ACAT), diacylglycerol AT (DGAT), and monoacylglycerol AT (MGAT) for the metabolism of lipids.
ACAT (acyl-coenzyme A:cholesterol acyltransferase) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and fatty acyl-coenzyme A. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles in cellular cholesterol homeostasis in various tissues.
DGAT (acyl-CoA:diacylglycerol acyltransferase) is an integral membrane enzyme that catalyses the last step of triacylglycerol synthesis from diacylglycerol and acyl-CoA. DGAT activity resides mainly in two distinct membrane bound polypeptides, known as DGAT1 and DGAT2.
MGAT (acyl-CoA:monoacylglycerol acyltransferase) catalyzes the synthesis of diacylglycerol, the precursor of physiologically important lipids such as triacylglycerol and phospholipids. In the intestine, MGAT plays a major role in the absorption of dietary fat because resynthesis of triacylglycerol is required for the assembly of lipoproteins that transport absorbed fat to other tissues.
Acyltransferase Isoform Specific Products
All Product Categories
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Acyltransferase Related Products (243)
Related Products (243)
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Antibodies (4)
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Acyltransferase Isoform Comparison
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Pactimibe sulfate (Standard)
0 ImagesCat. No.: HY-100401ARCAS No.: 608510-47-0Synonyms: CS-505 (Standard)Pactimibe (sulfate) (Standard) is the analytical standard of Pactimibe (sulfate) (HY-100401A). This product is intended for research and analytical applications. Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe sulfate (CS-505) inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively. Pactimibe sulfate (CS-505) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. Moreover, Pactimibe sulfate (CS-505) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 μM. Pactimibe sulfate (CS-505) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity.
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Gypsetin
0 ImagesCat. No.: HY-N14715CAS No.: 155114-38-8Gypsetin can inhibit acylcoenzyme A, cholesterol acyltransferase (ACAT) activity, inhibit rat liver microbody ACAT with an IC50 of 18 μM, and its action is competitive with oleoyl-COA substrate, Ki value is 5.5 μM. Gypsetin also inhibits Oleic acid from forming cholesterol esters with an IC50 of 0.65 μM.
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ALCAT1-IN-1
0 ImagesCat. No.: HY-150179CAS No.: 2245767-05-7ALCAT1-IN-1 is an ALCAT1 inhibitor.ALCAT1-IN-1 can be used for the research of aging and age-related diseases.
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PF-06471553 (Standard)
0 ImagesCat. No.: HY-108339RCAS No.: 1808094-07-6PF-06471553 (Standard) is the analytical standard of PF-06471553 (HY-108339). This product is intended for research and analytical applications. PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM.
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Purpactin A
0 ImagesCat. No.: HY-N9552CAS No.: 133806-59-4Purpactin A is a cholesterol acyltransferase (ACAT) inhibitor found in Pen. Purpurogenum FO-6.
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Roselipin 1A
0 ImagesCat. No.: HY-N14581CAS No.: 232258-17-2Roselipin 1A inhibits diacylglycerol acyltransferases (DGAT) of rat hepatic microcosm.
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TP-020 (Standard)
0 ImagesCat. No.: HY-101857RCAS No.: 1800025-30-2Synonyms: MGAT2-IN-1 (Standard)TP-020 (Standard) (MGAT2-IN-1 (Standard)) is the analytical standard of TP-020 (HY-101857). This product is intended for research and analytical applications. TP-020 (MGAT2-IN-1), a chemical probe, is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively.
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PF-06424439 (Standard)
0 ImagesCat. No.: HY-108341RCAS No.: 1469284-78-3PF-06424439 (Standard) is the analytical standard of PF-06424439 (HY-108341). This product is intended for research and analytical applications. PF-06424439 is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM. PF-06424439 is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate.
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A 922500 (Standard)
0 ImagesSynonyms: DGAT-1 Inhibitor 4a (Standard)A 922500 (Standard) is the analytical standard of A 922500 (HY-10038). This product is intended for research and analytical applications. A 922500 (DGAT-1 Inhibitor 4a) is a potent, selective, and orally bioavailable diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC50s of 9 and 22 nM against human and mouse DGAT-1, respectively.
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Roselipin 1B
0 ImagesCat. No.: HY-N14584CAS No.: 232258-18-3Roselipin 1B inhibits diacylglycerol acyltransferases (DGAT) of rat hepatic microcosm.
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Triethylcholine iodide
0 ImagesCat. No.: HY-W127668CAS No.: 5957-17-5Triethylcholine iodide is a choline acetyltransferase inhibitor and a regulator of the acetylcholine synthesis pathway. Triethylcholine iodide inhibits acetylcholine synthesis in brain tissues and blocks neuromuscular and autonomic ganglionic transmission. Triethylcholine iodide exerts weak curare-like effects at extremely high concentrations. Triethylcholine iodide elevates the pentylenetetrazol seizure threshold, alters electroencephalogram patterns in Felis catus, but does not affect the maximal electroshock seizure threshold in Oryctolagus cuniculus. Triethylcholine iodide can be used in seizure-related research.
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Glisoprenin B
0 ImagesCat. No.: HY-N14573CAS No.: 144376-63-6Glisoprenin B is a cholesterol acyltransferase (ACAT) inhibitor.
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Idalaptican pegol
0 ImagesCat. No.: HY-185926CAS No.: 2364414-05-9Synonyms: NOX-D21; AON-D21Ldalaptican pegol (AON-D21; NOX-D21) is a PEGylated mixed RNA/DNA L-aptamer that specifically binds to complement C5a. Ldalaptican pegol binds to C5a and the C5a moiety on uncleaved C5, thereby blocking C5a signaling. This inhibition suppresses downstream inflammatory responses, immune cell infiltration and chemotaxis, the release of pro-fibrotic factors, and abnormalities in lipid metabolism signaling pathways. Ldalaptican pegol can also alleviate allograft rejection. Ldalaptican pegol can be used in research on inflammatory muscle diseases, Duchenne muscular dystrophy (DMD), diabetes, renal fibrosis, and allograft organ transplant rejection.
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CMX410
0 ImagesCMX410 is an orally active and selective Mycobacterium tuberculosis Pks13 acyltransferase domain inhibitor and anti-bacterial agent. CMX410 reacts with the catalytic serine of the Pks13-AT domain to form a stable β-lactam ring, disables the enzyme’s active site, reduces trehalose monomycolate and trehalose dimycolate levels, triggers cell lysis, and reduces intracellular bacterial burden. CMX410 can be used for the research of tuberculosis.
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Roselipin 2A
0 ImagesCat. No.: HY-N14580CAS No.: 232258-26-3Roselipin 2A inhibits diacylglycerol acyltransferases (DGAT) of rat hepatic microcosm.
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Amidepsin B
0 ImagesCat. No.: HY-N14793CAS No.: 169181-29-7Amidepsin B is a diacylglycerol acyltransferase (DGAT) inhibitor.
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Amidepsin C
0 ImagesCat. No.: HY-N14794CAS No.: 169181-30-0Amidepsin C is a diacylglycerol acyltransferase (DGAT) inhibitor.
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Phenylpyropene B
0 ImagesCat. No.: HY-N14688CAS No.: 556013-83-3Phenylpyropene B can inhibit ACAT activity with IC50 of 12.8 μM.
