3027135-80-1
Chemical Structure
CMX410
- CAS No.: 3027135-80-1
- Formula:C16H13F3N4O6S2
- Molecular Weight:478.42
InChIKey: RDJADVVFBAIVKO-UHFFFAOYSA-N
SMILES: FC1=CC(N2N=C(NS(=O)(C)=O)N=C2)=CC(F)=C1COC3=CC=C(OS(F)(=O)=O)C=C3
Biological Activity: CMX410 is an orally active and selective Mycobacterium tuberculosis Pks13 acyltransferase domain inhibitor and anti-bacterial agent. CMX410 reacts with the catalytic serine of the Pks13-AT domain to form a stable β-lactam ring, disables the enzyme’s active site, reduces trehalose monomycolate and trehalose dimycolate levels, triggers cell lysis, and reduces intracellular bacterial burden. CMX410 can be used for the research of tuberculosis[1][2].
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CMX410 | 99.79% | CMX410 is an orally active and selective Mycobacterium tuberculosis Pks13 acyltransferase domain inhibitor and anti-bacterial agent. CMX410 reacts with the catalytic serine of the Pks13-AT domain to form a stable β-lactam ring, disables the enzyme’s active site, reduces trehalose monomycolate and trehalose dimycolate levels, triggers cell lysis, and reduces intracellular bacterial burden. CMX410 can be used for the research of tuberculosis. | ||||||||||||||||||||
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- [1]. Yang B, et al. Synthesis and structure-activity relationships of aryl fluorosulfate-based inhibitors as novel antitubercular agents. Bioorg Med Chem Lett. 2024;98:129596. [Content Brief]
- [2]. Krieger IV, et al. SuFEx-based antitubercular compound irreversibly inhibits Pks13. Nature. 2025;645(8081):755-763. [Content Brief]
Keywords
