179053-90-8
179053-90-8
Chemical Structure
FR186054
- CAS No.: 179053-90-8
- Formula:C26H27N5OS2
- Molecular Weight:489.66
IUPAC Name: 1-(3-(1H-pyrazol-3-yl)benzyl)-1-benzyl-3-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)urea
InChIKey: XCMUCRXXBCAKCO-UHFFFAOYSA-N
SMILES: O=C(N(CC1=CC=CC(C2=NNC=C2)=C1)CC3=CC=CC=C3)NC4=C(SC)N=C(C)C=C4SC
Biological Activity: FR186054 is an oral active acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor with the IC50 of 99 nM. FR186054 shows hypocholesterolemic effect and can be used for study of hypercholesterolemia and atherosclerosis[1][2].
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FR186054 | FR186054 is an oral active acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor with the IC50 of 99 nM. FR186054 shows hypocholesterolemic effect and can be used for study of hypercholesterolemia and atherosclerosis. | |||||||||||||||||||||
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References
- [1]. Tanaka A, et al. Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring. Bioorg Med Chem Lett. 1998;8(1):81-86. [Content Brief]
- [2]. Tanaka A, et al. Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylureas. J Med Chem. 1998;41(13):2390-2410. [Content Brief]
