166518-61-2
Chemical Structure
Avasimibe sodium
Synonym(s): CI-1011 sodium; PD-148515 sodium
- CAS No.: 166518-61-2
- Formula:C29H43NNaO4S
- Molecular Weight:524.72
IUPAC Name: 2,6-diisopropylphenyl (2-(2,4,6-triisopropylphenyl)acetyl)sulfamate, sodium salt
InChIKey: SAOUXTNFWKBDGI-UHFFFAOYSA-N
SMILES: [Na].O=C(NS(=O)(=O)OC=1C(=CC=CC1C(C)C)C(C)C)CC=2C(=CC(=CC2C(C)C)C(C)C)C(C)C
Biological Activity: Avasimibe sodium (CI-1011 sodium; PD-148515 sodium) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC50s of 24 and 9.2 µM for ACAT1 and ACAT2, respectively[1]. Avasimibe sodium can be used for the research of prostate cancer[2].
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Avasimibe sodium | Avasimibe sodium (CI-1011 sodium; PD-148515 sodium) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC50s of 24 and 9.2 µM for ACAT1 and ACAT2, respectively. Avasimibe sodium can be used for the research of prostate cancer. | |||||||||||||||||||||
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- [1]. Taichi Ohshiro,et al. Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1108-15. [Content Brief]
- [2]. Kangping Xiong, et al. The cholesterol esterification inhibitor avasimibe suppresses tumour proliferation and metastasis via the E2F-1 signalling pathway in prostate cancer.Cancer Cell Int. 2021 Aug 30;21(1):461. [Content Brief]
Keywords
