FAAH
Fatty acid amide hydrolase
FAAH (Fatty acid amide hydrolase) is a membrane-bound protein belonging to serine hydrolase family of enzymes.FAAH is responsible for the hydrolysis of a number of important endogenous fatty acid amides, including the endogenous cannabimimetic agent anandamide (AEA), the sleep-inducing compound oleamide, and the putative anti-inflammatory agent palmitoylethanolamide (PEA). FAAH plays a significant role in termination of signalling of a class of bioactive lipids called fatty acid amides (FAAs) both in the central nervous system (CNS) and peripheral tissues.
FAAH belongs to the amidase signature (AS) superfamily and is widely distributed in multicellular eukaryotes. FAAH has a key role in the control of the cannabinoid signaling, through the hydrolysis of the endocannabinoids anandamide and in some tissues 2-arachidonoylglycerol.
All Product Categories
-
FAAH Related Products (105)
Related Products (105)
-
Antibodies (1)
-
FAAH-IN-9
0 ImagesCat. No.: HY-121090CAS No.: 288862-89-5FAAH-IN-9 (compoud 59) is an irreversible oleoyl inhibitor of FAAH with Ki of 0.02 nM.
-
MK-3168 (12C)
0 ImagesCat. No.: HY-161965CAS No.: 1242441-26-4
-
CAY10435
0 ImagesCat. No.: HY-120650CAS No.: 288862-73-7
-
JNJ-42165279 dihydrochloride
0 ImagesCat. No.: HY-19636ACAS No.: 1346528-51-5JNJ-42165279 (dihydrochloride) is aFAAHinhibitor with IC50 of 70 nM and 313 nM for hFAAH and rFAAH, respectively.
-
URB-597 (Standard)
0 ImagesSynonyms: KDS-4103 (Standard)URB-597 (Standard) is the analytical standard of URB-597. This product is intended for research and analytical applications. URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. URB-597 inhibits FAAH activity with an IC50s of approximately 5 nM in rat brain membranes, 0.5 nM in intact rat neurons, 3 nM in human liver microsomes. Antidepressant-like effects. Analgesic activity.
-
AZ513
0 ImagesCat. No.: HY-169603CAS No.: 1335231-15-6AZ513 is a reversible FAAH inhibitor with an IC50s of 551 nM and 27 nM for human FAAH and rat FAAH, respectively. AZ513 inhibits Anandamide (HY-10863) hydrolysis in human FAAH-transfected HEK293 cells (IC50 of 360 nM).
-
FAAH-IN-1 (Standard)
0 ImagesCat. No.: HY-111389RCAS No.: 1242441-47-9
-
1-Monomyristin (Standard)
0 Images1-Monomyristin, extracted from Serenoa repens, inhibits the hydrolysis of 2-oleoylglycerol (IC50=32 μM) and fatty acid amide hydrolase (FAAH) activity (IC50=18 μM). 1-Monomyristin shows antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also antifungal activity against Candida albicans.
-
PHOP
0 ImagesCat. No.: HY-118210CAS No.: 288862-83-9PHOP is a fatty acid amide hydrolase (FAAH) inhibitor used to assess inhibitory activity in a fluorometric assay. PHOP can determine FAAH activity by measuring the amount of 4-pyridin-1-ylbutyric acid released by the enzyme in rat brain microsomes. PHOP demonstrates potential as a FAAH inhibitor and can directly measure FAAH activity by reversed-phase HPLC and fluorescence detection, providing a basis for the development of new inhibitors.
-
Redafamdastat (Standard)
0 ImagesCat. No.: HY-14376RCAS No.: 1020315-31-4Synonyms: PF-04457845 (Standard)Redafamdastat (Standard) is the analytical standard of Redafamdastat. This product is intended for research and analytical applications. Redafamdastat (PF-04457845) is a highly efficacious and selective FAAH inhibitor with IC50 values is 7.2±0.63 nM and 7.4±0.62 nM for hFAAH and rFAAH, respectively.
-
Carmofur (Standard)
0 ImagesSynonyms: HCFU (Standard)Carmofur (Standard) is the analytical standard of Carmofur. This product is intended for research and analytical applications. Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI).
-
FAAH-IN-2 (Standard)
0 ImagesCat. No.: HY-79511RCAS No.: 184475-71-6Synonyms: O-Desmorpholinopropyl Gefitinib (Standard)
-
SA72
0 ImagesCat. No.: HY-U00240CAS No.: 934809-60-6SA72 is a highly selective fatty acid amide hydrolase (FAAH) inhibitor.
