FAAH

Fatty acid amide hydrolase

FAAH

Related Products

FAAH (Fatty acid amide hydrolase) is a membrane-bound protein belonging to serine hydrolase family of enzymes.FAAH is responsible for the hydrolysis of a number of important endogenous fatty acid amides, including the endogenous cannabimimetic agent anandamide (AEA), the sleep-inducing compound oleamide, and the putative anti-inflammatory agent palmitoylethanolamide (PEA). FAAH plays a significant role in termination of signalling of a class of bioactive lipids called fatty acid amides (FAAs) both in the central nervous system (CNS) and peripheral tissues.

FAAH belongs to the amidase signature (AS) superfamily and is widely distributed in multicellular eukaryotes. FAAH has a key role in the control of the cannabinoid signaling, through the hydrolysis of the endocannabinoids anandamide and in some tissues 2-arachidonoylglycerol.

FAAH Verwandte Produkte (102)
Antibodies (1)

By Effects:	Inhibitors (90)

Art. -Nr.	Produktname	Wirkung	Reinheit	Chemical Structure

HY-N7062

JNJ-1661010	Inhibitor	99.77%
JNJ-1661010 (Takeda-25) a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC₅₀s of 34 and 33 nM for rat FAAH and human FAAH, respectively. JNJ-1661010 can cross the blood-brain barrier and used as broad-spectrum analgesics.

HY-18081

PF 750	Inhibitor	98.99%
PF 750 is a selective, covalent and brain-penetrant fatty acid amide hydrolase (FAAH) inhibitor. PF 750 covalently carbamylates FAAH's catalytic serine nucleophile to inactivate the enzyme.

HY-79511

FAAH-IN-2	Inhibitor	99.12%
FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is an inhibitor of FAAH. FAAH-IN-2 is a metabolite of Gefitinib (HY-50895).

HY-163733

AKU-005	Inhibitor	99.48%
AKU-005 is a FAAH and MAGL dual inhibitor with IC₅₀ values of 63, 389 nM for rat and human FAAH, respectively. AKU-005 has the potential for the research of trigeminal hyperalgesia.

HY-18544

AA38-3	Inhibitor	99.95%
AA38-3 is a serine hydrolase (SH) inhibitor. AA38-3 can inhibit three SHs, ABHD6, ABHD11, and FAAH.

HY-77491

FAAH/MAGL-IN-5	Inhibitor
AM6701 is a potent FAAH/MAGL inhibitor (equipotent inhibitory IC₅₀: 1.2 nM) with neuroprotective effects.

HY-N2428

N-(3-Methoxybenzyl)Palmitamide	Inhibitor	99.90%
N-(3-Methoxybenzyl)Palmitamide is a promising inhibitor of FAAH for the treatment of pain, inflammation and CNS degenerative disorders.

HY-10862

FAAH inhibitor 1	Inhibitor	98.30%
FAAH inhibitor 1 (compound 3) is a selective reversible FAAH inhibitor. FAAH inhibitor 1 has no off-target activity with respect to other serine hydrolases. FAAH inhibitor 1 is exclusively specific against FAAH in rat brain with an IC₅₀ value of 18 nM and had no missing protein bands in all the other tissues. FAAH inhibitor 1 can be used for neurological disorders research.

HY-103461

FAAH-IN-6	Inhibitor	99.70%
FAAH-IN-6 (compound 21d) is a potent, orally active and cross the blood-brain barrier fatty acid amide hydrolase (FAAH) inhibitor with IC₅₀s of 0.72, 0.28 nM for hFAAH, rFAAH, respectively. FAAH-IN-6 shows dose-dependent analgesic efficacy in animal models of both neuropathic and inflammatory pain.

HY-118158

FAAH/MAGL-IN-4	Inhibitor	99.83%
FAAH/MAGL-IN-4 (Compound 13) is a potent fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGL) inhibitor with IC₅₀s of 9.1 nM and 7.9 μM, respectively. FAAH/MAGL-IN-4 can be used for the research of pain and CNS disorders.

HY-177093

Irafamdastat	Inhibitor	98.07%
Irafamdastat (BMS-986368) (Example 74) is a FAAH and MAGL inhibitor, with IC₅₀s ≤ 100 nM (human FAAH) and 100 nM-1 μM (human MAGL) respectively. Irafamdastat has antiepileptic effect.

HY-103337

N-Arachidonoylserotonin	Inhibitor	99.11%
N-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC₅₀ value of 1~12 µM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC₅₀=70~100 nM). N-Arachidonoylserotonin is analgesic in rodents .

HY-111389

FAAH-IN-1	Inhibitor	99.59%
FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC₅₀s of 145 nM and 650 nM for rat and human FAAH, respectively.

HY-14595R

Biochanin A (Standard)	Inhibitor
Biochanin A (Standard) is the analytical standard of Biochanin A. This product is intended for research and analytical applications. Biochanin A is a naturally occurring fatty acid amide hydrolase (FAAH) inhibitor, which inhibits FAAH with IC₅₀s of 1.8, 1.4 and 2.4 μM for mouse, rat, and human FAAH, respectively.

HY-152254

CB2R/FAAH modulator-3	Inhibitor	99.71%
CB2R/FAAH modulator-3 (compound 27) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The K_i values for CB2R/FAAH modulator-3 are 20.1 and 67.6 nM for CB2R and CB1R, respectively, and the IC₅₀ value for FAAH is 3.4 μM. CB2R/FAAH modulator-3 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.

HY-18080

SA 47	Inhibitor	99.0%
SA 47 is a selective and potent inhibitor of fatty acid amide hydrolase (FAAH) and carbamate.

HY-N3033

N-Benzyllinolenamide	Inhibitor	99.70%
N-Benzyllinolenamide is a natural macamide isolated from Lepidium meyenii, acts as an inhibitor of fatty acid amide hydrolase (FAAH) with an IC₅₀ of 41.8 μM.

HY-18013

JNJ-40355003	Inhibitor	99.81%
JNJ-40355003 is a potent and selective atty acid amide hydrolase (FAAH) inhibitor.

HY-111199

JP83	Inhibitor	99.0%
JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor with an IC₅₀ of 1.6 nM in competitive activity-based protein profiling (ABPP) experiments.

HY-123863

SSR411298	Inhibitor	99.75%
SSR411298 is an orally active, selective and reversible fatty acid amide hydrolase (FAAH) inhibitor. SSR411298 has the potential for post-traumatic stress disorder research.

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FAAH

FAAH

FAAH Verwandte Produkte (102)

Antibodies (1)

FAAH Verwandte Produkte (102):