2244136-58-9
2244136-58-9
Chemical Structure
Irafamdastat
Synonym(s): BMS-986368; CC-97489; ABX-1772
- CAS No.: 2244136-58-9
- Formula:C20H21F3N4O4
- Molecular Weight:438.40
SMILES: NC(C1=CC(OC(N2[C@@H](CN(CC2)CC3=CC(OC(F)(F)F)=CC=C3)C)=O)=CN=C1)=O
Biological Activity: Irafamdastat (BMS-986368) (Example 74) is a FAAH and MAGL inhibitor, with IC50s ≤ 100 nM (human FAAH) and 100 nM-1 μM (human MAGL) respectively. Irafamdastat has antiepileptic effect[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Irafamdastat | 98.07% | Irafamdastat (BMS-986368) (Example 74) is a FAAH and MAGL inhibitor, with IC50s ≤ 100 nM (human FAAH) and 100 nM-1 μM (human MAGL) respectively. Irafamdastat has antiepileptic effect. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Cheryl A. Grice, et al. Dual magl and faah inhibitors. Patent. US20180256566A1
- [2]. Tim Depmeier, et al. Carbamates with ortho-Substituted O-Phenyl Groups as Dual Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: Inhibitory Potency, Hydrolytic Stability, and QSAR Studies. 2025. ACS Medicinal Chemistry Letters.
Keywords
