2244136-58-9
2244136-58-9
Chemical Structure
Irafamdastat
Synonym(s): BMS-986368; CC-97489; ABX-1772
- CAS No.: 2244136-58-9
- Formula:C20H21F3N4O4
- Molecular Weight:438.40
IUPAC Name: 5-carbamoylpyridin-3-yl (R)-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate
InChIKey: XXDVCULQMDDOAX-CYBMUJFWSA-N
SMILES: NC(C1=CC(OC(N2[C@@H](CN(CC2)CC3=CC(OC(F)(F)F)=CC=C3)C)=O)=CN=C1)=O
Biological Activity: Irafamdastat (BMS-986368) is a covalently acting FAAH and MAGL inhibitor that penetrates the central nervous system. Irafamdastat is used in research on Alzheimer's disease, multiple sclerosis, and epilepsy[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Irafamdastat | 98.07% | Irafamdastat (BMS-986368) is a covalently acting FAAH and MAGL inhibitor that penetrates the central nervous system. Irafamdastat is used in research on Alzheimer's disease, multiple sclerosis, and epilepsy. | ||||||||||||||||||||
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References
- [1]. van Laere K, et al. Central occupancy and peripheral inhibition of cannabinoid signaling by the dual FAAH/MAGL inhibitor irafamdastat (BMS-986368)[J].
- [2]. Depmeier T, et al. Carbamates with -Substituted ‑Phenyl Groups as Dual Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: Inhibitory Potency, Hydrolytic Stability, and QSAR Studies. ACS medicinal chemistry letters. 2025 Aug 14;16(8):1601-1609.
