2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. FAAH TRP Channel
  4. N-Arachidonoylserotonin

N-Arachidonoylserotonin  (Synonyms: Arachidonyl serotonin; AA-5-HT)

Cat. No.: HY-103337 Purity: 99.11%
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N-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 value of 1~12 µM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC50=70~100 nM). N-Arachidonoylserotonin is analgesic in rodents .

For research use only. We do not sell to patients.

N-Arachidonoylserotonin

N-Arachidonoylserotonin Chemical Structure

CAS No. : 187947-37-1

Size Price Stock Quantity
Solvent
5 mg (108.07 mM * 0.1 mL in Methyl acetate) In-stock
Solvent
10 mg (108.07 mM * 0.2 mL in Methyl acetate) In-stock
Solvent
25 mg (108.07 mM * 0.5 mL in Methyl acetate) In-stock
Solvent
50 mg (108.07 mM * 1 mL in Methyl acetate) In-stock

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Based on 1 publication(s) in Google Scholar

N-Arachidonoylserotonin Related Antibodies

Top Publications Citing Use of Products

View All TRP Channel Isoform Specific Products:

View All Isoforms
TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

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Description

N-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 value of 1~12 µM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC50=70~100 nM). N-Arachidonoylserotonin is analgesic in rodents [1].

IC50 & Target

IC50: 1~12 µM (FAAH), 70~100 nM (TRPV1 channels)[1]
Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
> 25 μM
Compound: AA-5-HT
Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as decrease in intracellular calcium level
Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as decrease in intracellular calcium level
[PMID: 19875281]
HEK293 IC50
0.27 μM
Compound: 1a, AA-5-HT
Antagonist activity at human recombinant TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular calcium elevation
Antagonist activity at human recombinant TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular calcium elevation
[PMID: 18027904]
Molecular Weight

462.67

Formula

C30H42N2O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(NCCC1=CNC2=C1C=C(O)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation
References
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N-Arachidonoylserotonin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Arachidonoylserotonin187947-37-1Arachidonyl serotonin AA-5-HTFAAHTRP ChannelFatty acid amide hydrolaseTransient receptor potential channelsAnalgesicRodentsInhibitorinhibitorinhibit

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