N-Arachidonoylserotonin
Based on 1 Customer Validation
N-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 value of 1~12 µM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC50=70~100 nM). N-Arachidonoylserotonin is analgesic in rodents .
For research use only. We do not sell to patients.
- Purity: 99.11%
- CAS No.: 187947-37-1
- Formula: C30H42N2O2
- Molecular Weight:462.67
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Storage:
Solution, -20°C, 2 years
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1~12 µM (FAAH), 70~100 nM (TRPV1 channels)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
>25 μM
Compound: AA-5-HT
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Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as decrease in intracellular calcium level
Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as decrease in intracellular calcium level
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[PMID: 19875281] |
| HEK293 | IC50 |
0.27 μM
Compound: 1a, AA-5-HT
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Antagonist activity at human recombinant TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular calcium elevation
Antagonist activity at human recombinant TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular calcium elevation
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[PMID: 18027904] |
Chemical Information
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CAS No. 187947-37-1
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Appearance Liquid
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Molecular Weight 462.67
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Formula C30H42N2O2
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Color Colorless to light yellow
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SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(NCCC1=CNC2=C1C=C(O)C=C2)=O
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Synonyms
Arachidonyl serotonin; AA-5-HT
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (262 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N-Arachidonoylserotonin Related Classifications
HY-103337 Related Classifications
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