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Cat. No.: HY-18080

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SA 47

Name: SA 47
Brand: MedChemExpress
SKU: HY-18080
Availability: PreOrder

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

SA 47 is a selective fatty acid amide hydrolase (FAAH) inhibitor. SA 47 inhibits FAAH enzyme activity and disrupts the NLRP3-FAAH interaction, promoting K48 ubiquitination and selective autophagic degradation of NLRP3. SA 47 reduces NLRP3 protein levels in macrophages. SA 47 can be used for research on inflammatory diseases associated with NLRP3 protein mutations.

For research use only. We do not sell to patients.

Purity : 99.0%
CAS No.: 792236-07-8
Formula: C₁₇H₂₆N₄O₃
Molecular Weight:334.41

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

SA 47 Chemical Structure

CAS No.: 792236-07-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
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Biological Activity

Description

IC₅₀ & Target

FAAH, Carbamate^[1].

All FAAH Isoforms :

In Vitro

SA 47 (40 μM) induces NLRP3 protein degradation in BMDMs, reducing NLRP3 protein levels by more than 30%^[1].
SA 47 (10 μM; 30 min) does not inhibit any of the seven cloned rat carboxylesterases in HEK293T cells (X51974/TGH/ES10, NM_031565/ES3, NM_133586/ES2, NM_144743, NM_017004, X81825/ES4, and NM_001024365)^[2].
SA 47 (10 μM; 30 min) does not significantly inhibit carboxylesterase activity in rat liver microsomes or cytosol^[2].
SA 47 shows excellent selectivity for FAAH in both mouse and human tissues, with no significant off-target effects at 10 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 792236-07-8
Appearance Solid
Molecular Weight 334.41
Formula C₁₇H₂₆N₄O₃
Color White to off-white
SMILES

CNC(COC(NCCC(CC1)CCN1C2=CC=CC(C)=N2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Cell Death Differ

FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system. [Abstract]

2023 Jan;30(1):168-183. PMID: 36104448

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wen L P, et al. Use of an agent that inhibits or blocks the interaction between FAAH and NLRP3. CN patent, CN115616216A. 2023.

[2]. Zhang D, et al. Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets. Neuropharmacology. 2007 Mar;52(4):1095-105. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References

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SA 47

Publications Citing Use of MedChemExpress (MCE) SA 47

All FAAH Isoforms