792236-07-8
Chemical Structure
SA 47
- CAS. Nr.: 792236-07-8
- Formula:C17H26N4O3
- Molecular Weight:334.41
IUPAC Name: 2-(methylamino)-2-oxoethyl (2-(1-(6-methylpyridin-2-yl)piperidin-4-yl)ethyl)carbamate
InChIKey: HSYCMGWPPRTNKH-UHFFFAOYSA-N
SMILES: CNC(COC(NCCC(CC1)CCN1C2=CC=CC(C)=N2)=O)=O
Biological Activity: SA 47 is a selective fatty acid amide hydrolase (FAAH) inhibitor. SA 47 inhibits FAAH enzyme activity and disrupts the NLRP3-FAAH interaction, promoting K48 ubiquitination and selective autophagic degradation of NLRP3. SA 47 reduces NLRP3 protein levels in macrophages. SA 47 can be used for research on inflammatory diseases associated with NLRP3 protein mutations[1][2].
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SA 47 | 99.0% | SA 47 is a selective fatty acid amide hydrolase (FAAH) inhibitor. SA 47 inhibits FAAH enzyme activity and disrupts the NLRP3-FAAH interaction, promoting K48 ubiquitination and selective autophagic degradation of NLRP3. SA 47 reduces NLRP3 protein levels in macrophages. SA 47 can be used for research on inflammatory diseases associated with NLRP3 protein mutations. | ||||||||||||||||||||
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References
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[1]. Wen L P, et al. Use of an agent that inhibits or blocks the interaction between FAAH and NLRP3. CN patent, CN115616216A. 2023.
- [2]. Zhang D, et al. Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets. Neuropharmacology. 2007 Mar;52(4):1095-105. [Content Brief]
