86855-26-7
86855-26-7
Chemical Structure
AM 374
- CAS No.: 86855-26-7
- Formula:C16H33FO2S
- Molecular Weight:308.50
IUPAC Name: hexadecane-1-sulfonyl fluoride
InChIKey: QIVFMUVBIHIZAM-UHFFFAOYSA-N
SMILES: CCCCCCCCCCCCCCCCS(=O)(F)=O
Biological Activity: AM 374 is an fatty acid amide hydrolase (FAAH) inhibitor. AM 374 inhibits amidase activity with an IC50 value of 13 nM. AM 374 can be used for the research of neurological disease[1][2].
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AM 374 | 97.0% | AM 374 is an fatty acid amide hydrolase (FAAH) inhibitor. AM 374 inhibits amidase activity with an IC50 value of 13 nM. AM 374 can be used for the research of neurological disease. | ||||||||||||||||||||
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References
- [1]. Deutsch DG, et al. Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. Biochem Biophys Res Commun. 1997 Feb 3;231(1):217-21. [Content Brief]
- [2]. Arizzi MN, et al. Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide. Life Sci. 2004 Jan 9;74(8):1001-11. [Content Brief]
Keywords
