Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2719)
Related Products (2719)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Bethoxazin
0 ImagesBethoxazin is a yeast DNA topoisomerase II inhibitor with an IC50 of 5.3 μM, and also a broad-spectrum industrial microbicide and covalent adduct-forming agent. Bethoxazin inhibits the catalytic activity of yeast DNA topoisomerase II by reacting with the key free cysteine thiol group on the enzyme. Bethoxazin forms covalent adducts with molecules containing free thiol groups. Bethoxazin inhibits the growth of yeast cells. Bethoxazin can be used in studies related to the growth of fungi, molds and algae.
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Ravuconazole (Standard)
0 ImagesSynonyms: BMS-207147 (Standard); ER-30346 (Standard)Ravuconazole (Standard) is the analytical standard of Ravuconazole. This product is intended for research and analytical applications. Ravuconazole (BMS-207147;ER-30346) is an orally available triazole antifungle agent that potently inhibits a wide range of fungi.
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Haliangicin C
0 ImagesCat. No.: HY-N14443CAS No.: 661466-87-1Haliangicin C has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
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Ramulosin
0 ImagesCat. No.: HY-N14585CAS No.: 29914-01-0Ramulosin has an antifungal effect and inhibits the germination of fungal meristems.
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Silthiofam (Standard)
0 ImagesCat. No.: HY-123096RCAS No.: 175217-20-6Synonyms: Silthiopham (Standard); Mon65500 (Standard)Silthiofam (Standard) is the analytical standard of Silthiofam. This product is intended for research and analytical applications. Silthiofam (Silthiopham) is a wheat fungicide used to control take-all disease caused by the soil-borne fungus Gaeumannomyces graminis.
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DT-23
0 ImagesCat. No.: HY-173452DT-23 is a potent antifungal agent with an MIC50 of 15 μg/mL. DT-23 inhibits recombinant Arg1 and Kcs1 with IC50s of 0.6 and 0.68 μM, respectively.
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Frenolicin
0 ImagesCat. No.: HY-N14995CAS No.: 10023-07-1Frenolicin is an antibiotic with antibacterial activity. Frenolicin also exhibits cytotoxicity against tumor cells.
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Hypnophilin
0 ImagesCat. No.: HY-N15082CAS No.: 80677-96-9Hypnophilin has a variety of activities, including anti-Gram-positive bacteria, negative bacteria, yeast, mold and tumor activities.
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Mycobacillin
0 ImagesCat. No.: HY-N14799CAS No.: 18524-67-9Mycobacillin is a peptide antibiotic with anti-antifungal activity.
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Alexidine dihydrochloride (Standard)
0 ImagesAlexidine (dihydrochloride) (Standard) is the analytical standard of Alexidine (dihydrochloride). This product is intended for research and analytical applications. Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens.
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Alliacol B
0 ImagesCat. No.: HY-N13906CAS No.: 79232-33-0Alliacol B is an antibiotic shows weak antibacterial and antifungal activity. Alliacol B inhibits DNA synthesis in cells of the ascitic form of Ehrlich carcinoma.
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De-N-methylpamamycin-593A
0 ImagesCat. No.: HY-N14729CAS No.: 226722-69-6De-N-methylpamamycin-593A is a 16-membered ring macrocyclic dilactone. De-N-methylpamamycin-593A has Aerial Mycelium-inducing activity.
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Asulam potassium
0 ImagesCat. No.: HY-B1838ACAS No.: 14089-43-1Asulam (potassium salt) is a chitin synthase inhibitor against plant pathogenic fungi. Asulam (potassium salt) interferes with the biosynthesis of chitin in the fungal cell wall to destroy the integrity and normal growth and reproduction of fungal cells, thereby exerting bacteriostatic activity. Asulam (potassium salt) is promising for research of fungal diseases such as downy mildew and gray mold in spinach, tulips, daffodils and lilies.
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PPm
0 ImagesCat. No.: HY-157218CAS No.: 2101951-47-5PPm, a derivative of penthiopyrad and hapten, is a representative member of the succinate dehydrogenase inhibitors group of fungicides.
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Candicidin D
0 ImagesCat. No.: HY-125152CAS No.: 39372-30-0Synonyms: CndDCandicidin D (CndD) is an antibiotic, which exhibits antifungal activity through interaction with steroids in cell membranes. Candicidin D inhibits S. cerevisiae, Candida albicans and other Candida spp. with MIC of 0.25-1 μg/mL in RPMI-1640 medium.
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Ascr#18 (Standard)
0 ImagesCat. No.: HY-N8393RCAS No.: 1355681-10-5Ascr#18 (Standard) is the analytical standard of Ascr#18 (HY-N8393). This product is intended for research and analytical applications. Ascr#18, an ascaroside, is a hormone of nematodes. Ascr#18 is expressed during nematode development. Ascr#18 increases resistance in Arabidopsis, tomato, potato and barley to viral, bacterial, oomycete, fungal and nematode infections.
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Olorofim (Standard)
0 ImagesSynonyms: F901318 (Standard)Olorofim (Standard) is the analytical standard of Olorofim (HY-104029). This product is intended for research and analytical applications. Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318). Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp..
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Eupolauridine
0 ImagesCat. No.: HY-N15319CAS No.: 58786-39-3Synonyms: CanangineEupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC50 values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases.
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SPK-843
0 ImagesCat. No.: HY-109125CAS No.: 143483-67-4Synonyms: SPA-S-753 free baseSPK-843 is an antifungal agent. SPK-843 shows inhibitory activity against A. fumigatus MF-13, A. flavus TIMM 0057, and A. niger TIMM 2814 with MICs of 0.5 μg/mL, 0.25 μg/mL, and 0.0625 μg/mL, respectively. SPK-843 exhibits dose-dependent efficacy in murine models of pulmonary aspergillosis. SPK-843 can be used for the research of related fungal infections.
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SDH-IN-32
0 ImagesCat. No.: HY-178196SDH-IN-32 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 2.74 μM. SDH-IN-32 exhibits excellent antifungal activity. SDH-IN-32 can destroy the cell membrane structure and increase the permeability of the cell membrane. SDH-IN-32 can decrease the mitochondrial membrane potential (MMP), thereby inducing cell apoptosis and inhibiting the normal growth of mycelia. SDH-IN-32 can be used for the research of infection.
