Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
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Fungal Related Products (2720)
Related Products (2720)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Sakuranetin (Standard)
0 ImagesSakuranetin is a cherry flavonoid phytoalexin, shows strong antifungal activity. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury.
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Silthiofam
0 ImagesCat. No.: HY-123096CAS No.: 175217-20-6Synonyms: Silthiopham; Mon65500Silthiofam (Silthiopham) is a wheat fungicide used to control take-all disease caused by the soil-borne fungus Gaeumannomyces graminis.
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Haliangicin A
0 ImagesCat. No.: HY-N14441CAS No.: 290354-00-6Haliangicin A has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
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Tebuconazole-d6
0 ImagesCat. No.: HY-B0852S2Tebuconazole-d6 is a deuterium labeled Tebuconazole (HY-B0852). Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells.
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5,6,7,8-Tetramethoxyflavone
0 Images5,6,7,8-Tetramethoxyflavone is a flavonoid with antifungal and antibacterial activities, capable of inhibiting the growth of *Staphylococcus aureus* and *Candida albicans*. 5,6,7,8-Tetramethoxyflavone can be utilized in research related to infections [1].
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(E)-Isoeugenol acetate
0 Images(E)-Isoeugenol acetate, a Eugenol derivative, possesses antifungal activity.
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Aloin (mixture of A&B) (Standard)
0 ImagesAloin (mixture of A&B) (Standard) is the analytical standard of Aloin (mixture of A&B) (HY-N6013). This product is intended for research and analytical applications. Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma.
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Succinate dehydrogenase-IN-13
0 ImagesCat. No.: HY-187509Succinate dehydrogenase-IN-13 is a succinate dehydrogenase inhibitor with an IC50 of 8.69 μM against Rhizoctonia solani. Succinate dehydrogenase-IN-13 binds stably within the succinate dehydrogenase active site to disrupt fungal respiration and energy metabolism, and induces hyphal distortion and mitochondrial damage in Rhizoctonia solani. Succinate dehydrogenase-IN-13 reduces intracellular ATP levels in Rhizoctonia solani mycelia. Succinate dehydrogenase-IN-13 can be used for the research of Rhizoctonia solani infection, Botrytis cinerea infection.
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Anti-MRSA agent 35
0 ImagesCat. No.: HY-178108Anti-MRSA agent 35 (Compound 6b) is an anti-MRSA agent. Anti-MRSA agent 35 significantly inhibits MRSA biofilm formation, suppresses penicillin-binding protein (PBP2a) expression and induces mecA virulence gene mutation. Anti-MRSA agent 35 has potent bactericidal and fungicidal activities with MIC50s of 7.8-31.25 μg/mL for gram positive bacteria, gram-negative bacteria and Fungi. .
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Mandipropamid (Standard)
0 ImagesCat. No.: HY-W744966RCAS No.: 374726-62-2Mandipropamid (Standard) is the analytical standard of Mandipropamid (HY-W744966). This product is intended for research and analytical applications. Mandipropamid is a cellulose synthase (CesA3) inhibitor and fungicide, with an IC50 of 19.8 nM against Phytophthora infestans. Mandipropamid inhibits the synthesis of crystalline cellulose on the cell surface, disrupts the cell wall structure of oomycetes, and induces germ tube tip swelling and growth arrest in Phytophthora infestans. S-Mandipropamid, an isomer of Mandipropamid, exhibits enantioselective acute toxicity to zebrafish embryos and larvae. Mandipropamid is applicable to studies related to plant infections.
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Phosmidosine
0 ImagesCat. No.: HY-N15110CAS No.: 134966-01-1Phosmidosine can inhibit the cell cycle progression and cell morphology recovery of srcts-NRK cells. Phosmidosine A has antifungal effects.
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Laccase-IN-3
0 ImagesCat. No.: HY-162488Laccase-IN-3 (Compound 2b) is a laccase inhibitor (IC50 = 1.02= μM) with significant antifungal activity. Laccase-IN-3 shows superior inhibitory effect on Botryosphaeria dothidea (EC50 = 0.17 mg/L). Laccase-IN-3 effectively blocks the catalytic function of laccase by binding to its active center. Laccase-IN-3 also disrupts pathogen cell membrane integrity and increases ROS.
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Becliconazole
0 ImagesCat. No.: HY-W714655CAS No.: 112893-26-2
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Cranberry Extract
0 ImagesCat. No.: HY-N13200Cranberry Extract is the extract of Cranberry, with content of 25% -50% Proanthocyanidins. Cranberry Extract exhibits anti-virus and antimicrbiol activity. Cranberry Extract suppresses fungal growth and biofilm formation. Cranberry Extract reduces NF-κB p65 phosphorylation, and PI3K/AKT signaling; increases caspase-8/9 activity to induce apoptosis, modulates oxidative stress, inflammation, and lipid profiles. Cranberry Extract exerts antiproliferative effects and induces cell cycle arrest. Cranberry Extract can be used for the research of infection and cancers.
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Pradimicin L
0 ImagesCat. No.: HY-169856CAS No.: 142062-87-1Pradimicin L is a homologue of pradimicin A (HY-132191) that can be isolated from the new type of Streptomyces madurensis, and it has antifungal activity.
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RNA splicing modulator 6
0 ImagesCat. No.: HY-W278073CAS No.: 430443-35-9RNA splicing modulator 6 (Compound c7) is a RNA splicing modulator. RNA splicing modulator 6 induces changes in pre-mRNA splicing. RNA splicing modulator 6 causes accumulation of unspliced RNA in the Hs-Hsh155 strain. RNA splicing modulator 6 reduces proliferation of chronic myeloid leukemia cells harboring the cancer-associated SRSF2P95H mutation.
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Tetraconazole (Standard)
0 ImagesCat. No.: HY-117089RCAS No.: 112281-77-3Tetraconazole (Standard) is the analytical standard of Tetraconazole. This product is intended for research and analytical applications. Tetraconazole, a chiral triazole fungicide, is widely used for the prevention of plant disease in wheat fields. Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds.
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Bagremycin A
0 ImagesCat. No.: HY-N13962CAS No.: 377775-45-6Bagremycin A is found in the strain of Streptomyce sp. Tu 4128. Bagremycin A has weak activity against Gram-positive bacteria, Saccharomyces cerevisiae and Candida albicans.
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2,4,6-Tribromophenyl caproate (Standard)
0 ImagesCat. No.: HY-101506RCAS No.: 16732-09-52,4,6-Tribromophenyl caproate (Standard) is the analytical standard of 2,4,6-Tribromophenyl caproate (HY-101506). This product is intended for research and analytical applications. 2,4,6-Tribromophenyl caproate (2,4,6-tribromophenyl caproic acid ester) is an anti-fungal agent.
