112281-77-3
Chemical Structure
Tetraconazole
- CAS No.: 112281-77-3
- Formula:C13H11Cl2F4N3O
- Molecular Weight:372.15
IUPAC Name: 1-(2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl)-1H-1,2,4-triazole
InChIKey: LQDARGUHUSPFNL-UHFFFAOYSA-N
SMILES: FC(F)C(F)(F)OCC(C1=CC=C(Cl)C=C1Cl)CN2N=CN=C2
Biological Activity: Tetraconazole is a selective irreversible inhibitor of 14-α-sterol demethylase (CYP51) with antifungal activity. Tetraconazole competitively binds to the enzyme to block fungal ergosterol synthesis, resulting in cell membrane damage. The EC50 of tetraconazole against wheat pathogens is 0.382-0.802 mg/L, and the EC50 against onion root tip meristem cell growth is 6.7 mg/L, and (R)-(+)-Tetraconazole is 1.49-1.98 times more active than (S)-(-)-Tetraconazole. Tetraconazole can also induce oxidative stress and chromosomal aberrations in plant cells[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tetraconazole | 96.98% | Tetraconazole is a selective irreversible inhibitor of 14-α-sterol demethylase (CYP51) with antifungal activity. Tetraconazole competitively binds to the enzyme to block fungal ergosterol synthesis, resulting in cell membrane damage. The EC50 of tetraconazole against wheat pathogens is 0.382-0.802 mg/L, and the EC50 against onion root tip meristem cell growth is 6.7 mg/L, and (R)-(+)-Tetraconazole is 1.49-1.98 times more active than (S)-(-)-Tetraconazole. Tetraconazole can also induce oxidative stress and chromosomal aberrations in plant cells. | ||||||||||||||||||||
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Tetraconazole (Standard) | ≥98% | Tetraconazole (Standard) is the analytical standard of Tetraconazole. This product is intended for research and analytical applications. Tetraconazole, a chiral triazole fungicide, is widely used for the prevention of plant disease in wheat fields. Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds. | ||||||||||||||||||||
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- [1]. Tong Z, et al. Enantioselective effects of the chiral fungicide tetraconazole in wheat: Fungicidal activity and degradation behavior. Environ Pollut. 2019;247:1-8. [Content Brief]
- [2]. Sieiro-Sampedro T, et al. Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds. Food Res Int. 2020;130:108930. [Content Brief]
- [3]. Macar O. Multiple toxic effects of tetraconazole in Allium cepa L. meristematic cells. Environ Sci Pollut Res Int. 2021 Feb;28(8):10092-10099. [Content Brief]
