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Cat. No.: HY-187509

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Succinate dehydrogenase-IN-13

Succinate dehydrogenase-IN-13 is a succinate dehydrogenase inhibitor with an IC₅₀ of 8.69 μM against Rhizoctonia solani. Succinate dehydrogenase-IN-13 binds stably within the succinate dehydrogenase active site to disrupt fungal respiration and energy metabolism, and induces hyphal distortion and mitochondrial damage in Rhizoctonia solani. Succinate dehydrogenase-IN-13 reduces intracellular ATP levels in Rhizoctonia solani mycelia. Succinate dehydrogenase-IN-13 can be used for the research of Rhizoctonia solani infection, Botrytis cinerea infection.

For research use only. We do not sell to patients.

Formula: C₁₆H₁₀F₂N₂O₂
Molecular Weight:300.26

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Please store the product under the recommended conditions in the Certificate of Analysis.

Succinate dehydrogenase-IN-13 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Succinate dehydrogenase-IN-13 (Compound 3p) (0.63-50 μg/mL) potently inhibits mycelial growth of Rhizoctonia solani with an EC₅₀ of 1.16 μg/mL, Botrytis cinerea with an EC₅₀ of 5.05 μg/mL^[1].
Succinate dehydrogenase-IN-13 (10 μg/mL; 2 days) induces severe morphological distortion, folding, and deformity in Rhizoctonia solani hyphae after 2 days of incubation^[1].
Succinate dehydrogenase-IN-13 (10 μg/mL; 24 h) causes thickened cell walls and blurred mitochondrial cristae in Rhizoctonia solani mycelia after 24 h of treatment^[1].
Succinate dehydrogenase-IN-13 (50 μg/mL; 2 days) reduces intracellular ATP levels in Rhizoctonia solani mycelia to 72% of the control after 2 days of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 300.26
Formula C₁₆H₁₀F₂N₂O₂
SMILES

O=C1C=CC2=C(O1)C=CC(/C=N/NC3=C(F)C=CC=C3F)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen W, et al. Coumarin Hydrazone Derivatives as Potent Succinate Dehydrogenase Inhibitors and Effective Antifungal Agents against Rhizoctonia solani. Journal of agricultural and food chemistry. 2026 Jul 29;74(29):22497-22506.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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