Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2723)
Related Products (2723)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Halofantrine hydrochloride (Standard)
0 ImagesCat. No.: HY-A0148ARCAS No.: 36167-63-2Synonyms: SKF-102886 (Standard); WR-171669 hydrochloride (Standard)Halofantrine hydrochloride (Standard) is the analytical standard of Halofantrine hydrochloride. This product is intended for research and analytical applications. Halofantrine hydrochloride (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent. Halofantrine hydrochloride inhibits the Cap1-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine hydrochloride can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria.
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AB5046A
0 ImagesCat. No.: HY-118058CAS No.: 154037-62-4AB5046A is a novel chlorosis-inducing substance. AB5046A can be isolated from Nodulisporium sp.. AB5046A induces chlorosis against Japanese barnyard millet.
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Graveoline (Standard)
0 ImagesGraveoline (Standard) is the analytical standard of Graveoline (HY-12538). This product is intended for research and analytical applications. Graveoline (Rutamine) is an orally active alkaloid with various activities such as antifungal, antiparasitic, anti-inflammatory, and antitumor effects. Graveoline can induce tumor cell apoptosis and autophagy through a reactive oxygen species-mediated pathway. Graveoline has an MIC of 500 μg/mL for Candida albicans. Graveoline can be used in the research of various diseases such as tumors and liver injury.
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Quindecamine acetate
0 ImagesCat. No.: HY-163688CAS No.: 19146-62-4Quindecamine acetate is a derivative of Quinaldine. Quindecamine acetate has antifungal activity.
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Amycolatopsin B
0 ImagesCat. No.: HY-N13156CAS No.: 2209112-97-8Amycolatopsin B (compound 2) is a glycosylated polyketide macrolide with antifungal activity that was isolated from the soil isolate Amycolatopsis sp. MST-108494.
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Neoenactin A
0 ImagesCat. No.: HY-N14838CAS No.: 88231-85-0Neoenactin A has strong anti-yeastlike and filamentous fungal effects.
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Neticonazole (Standard)
0 ImagesNeticonazole (Standard) is the analytical standard of Neticonazole. This product is intended for research and analytical applications. Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole has anti-infection and anti-cancer effects.
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Merulidial
0 ImagesCat. No.: HY-N15600CAS No.: 68053-32-7Synonyms: (-)-MerulidialMerulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum). Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC50 s of 20 and 10 μg/mL for ECA and L1210 cells, respectively .
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FTR1335
0 ImagesCat. No.: HY-183872CAS No.: 851075-79-1FTR1335 is an Antifungal agent as well as a selective, substrate peptide-competitive, and myristoyl-CoA non-competitive inhibitor of N-myristoyltransferase CaNmt, with an IC50 of 0.49 nM against Candida albicans CaNmt. FTR1335 exhibits fungicidal activity against Candida albicans and inhibits the growth of Candida tropicalis. FTR1335 can be used in research related to Candida albicans infections.
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BE-31405
0 ImagesCat. No.: HY-117092CAS No.: 158054-02-5BE-31405 is an antifungal antibiotic. BE-31405 can be isolated from the culture broth of the fungal strains such as Penicillium minioluteum F31405, Talaromyces siamensis FKA-61, and Phomopsis sp. FKA-62. BE-31405 exhibits potent growth inhibitory activity against pathogenic fungal strains including Candida albicans, Candida glabrata, and Cryptococcus neoformans. BE-31405 shows no cytotoxicity against mammalian cells.
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tert-Butyl cinnamate
0 ImagesCat. No.: HY-W558657ACAS No.: 14990-09-1Tert-Butyl cinnamate is a tert-butyl cinnamate with antifungal activity and comonomer function, which exhibits an average inhibition rate of 73.0% against phytopathogenic fungi at a concentration of 0.5 mM. Tert-Butyl cinnamate can be used in studies related to phytopathogenic fungal infections.
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Picoxystrobin (Standard)
0 ImagesPicoxystrobin (Standard) is the analytical standard of Picoxystrobin (HY-136355). This product is intended for research and analytical applications. Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity.
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Dichlorophen (Standard)
0 ImagesDichlorophen (Standard) is the analytical standard of Dichlorophen (HY-12638). This product is intended for research and analytical applications. Dichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections.
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Dipyrithione (Standard)
0 ImagesDipyrithione (Standard) is the analytical standard of Dipyrithione (HY-N8432). This product is intended for research and analytical applications. Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis.
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Pinselin
0 ImagesPinselin is a nitrogen-containing heterocyclic antibiotic. Pinselin has anti-yeast activity.
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Cyclo(L-leucyl-L-valyl)
0 ImagesCyclo(L-leucyl-L-valyl) inhibits Aflatoxin production by Aspergillus parasiticus.Cyclo(L-leucyl-L-valyl) inhibits transcription of the Aflatoxin-related genes aflR, hexB, pksL1, and dmtA..
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Fosetyl-aluminum (Standard)
0 ImagesCat. No.: HY-136425RCAS No.: 39148-24-8Synonyms: Fosetyl-Al (Standard)Fosetyl-aluminum (Standard) is the analytical standard of Fosetyl-aluminum. This product is intended for research and analytical applications. Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops.
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Pinosylvin monomethyl ether (Standard)
0 ImagesCat. No.: HY-N3056RCAS No.: 35302-70-6Pinosylvin monomethyl ether (Standard) is the analytical standard of Pinosylvin monomethyl ether. This product is intended for research and analytical applications. Pinosylvin monomethyl ether has antibacterial effect and fungicidal activity.
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Fulvoferruginin
0 ImagesCat. No.: HY-N14956CAS No.: 130100-07-1Fulvoferruginin showed cytotoxicity and antifungal activity, especially to Paecilomyces varioti.
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Maltophilin
0 ImagesCat. No.: HY-N14192CAS No.: 184877-66-5Maltophilin is a broad-spectrum antifungal antibiotic that has no antibacterial effect against Gram-positive and Gram-negative bacteria.
