Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
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Fungal Produits associés (2723)
Produits associés (2723)
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Anticorps (1)
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Related Compound Screening Libraries (1)
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Flucytosine-15N2 (hydrochloride)
0 ImagesCat. No.: HY-B0139AS1Synonyms: 5-Fluorocytosine-15N2 hydrochloride; NSC 103805-15N2 hydrochloride; Ro 2-9915-15N2 hydrochlorideFlucytosine-15N2 (5-Fluorocytosine-15N2) hydrochloride is the 15N-labeled Flucytosine hydrochloride (HY-B0139). Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells.
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(+)-β-Pinene
0 ImagesCat. No.: HY-W716339CAS No.: 19902-08-0Synonyms: d-β-Pinene(+)-β-Pinene (d-β-Pinene) acts as an Antifungal and Antibacterial agent. (+)-β-Pinene inhibits Phospholipase. (+)-β-Pinene interferes with fungal cell wall function, reduces Candida biofilm adhesion, inhibits Candida albicans biofilm formation, and suppresses the growth of various Candida species. Combined with Ciprofloxacin (HY-B0356), (+)-β-Pinene exerts synergistic antibacterial activity against Methicillin (HY-121544)-resistant Staphylococcus aureus. (+)-β-Pinene can be used in research related to candidiasis and Staphylococcus aureus infections.
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Triticonazole (Standard)
0 ImagesCat. No.: HY-B2058RCAS No.: 131983-72-7Triticonazole (Standard) is the analytical standard of Triticonazole. This product is intended for research and analytical applications. Triticonazole is a triazole pesticide. Triticonazole is an azole fungicide and shows endocrine disrupting activities.
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Pilatin
0 ImagesCat. No.: HY-N14659CAS No.: 119525-97-2Pilatin has inhibitory effects on bacteria and fungi, and has strong inhibitory effects on the incorporation of thymidin and ureidin into DNA and RNA in Ehrlich carcinoma ascites cells.
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Aculeacin A
0 ImagesCat. No.: HY-W747508CAS No.: 58814-86-1Aculeacin A is a β-1,3-glucan synthase inhibitor. Aculeacin A is an antifungal antibiotic. Aculeacin A inhibits cell wall glucan synthesis in growing yeast cells, induces cell lysis, osmotic fragility, cell aggregation and abnormal cell morphology, without affecting the synthesis of proteins, nucleic acids or mannan. Aculeacin A acts only on growing yeast cells and has a narrow antifungal spectrum, mainly targeting Candida and Torulopsis species. Aculeacin A shows reduced activity in human serum and exhibits a paradoxical dose-response pattern. Aculeacin A has an inoculum effect against some Candida albicans strains, and its activity is pH-stable. Aculeacin A can be used in studies of fungal infections, such as those caused by Candida, Torulopsis and other species.
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Sulfometuron-methyl (Standard)
0 ImagesCat. No.: HY-B1852RCAS No.: 74222-97-2Sulfometuron-methyl (Standard) is the analytical standard of Sulfometuron-methyl. This product is intended for research and analytical applications. Sulfometuron-methyl is a herbicide and also a powerful inhibitor of the enzyme acetolactate synthase (ALS). It exhibits antibacterial and antifungal activities, capable of inhibiting the activity of Salmonella. typhimurium ALS II and Escherichia. coli ALS III.
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Pipercroside A
0 ImagesCat. No.: HY-N15528CAS No.: 3053945-91-5Pipercroside A is found in Piper crocatum Ruiz & Pav. Pipercroside A is a CYP51 inhibitor. Pipercroside A has antifungal activity.
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Dehydrogriseofulvin
0 ImagesCat. No.: HY-W741556CAS No.: 3573-90-8Dehydrogriseofulvin can be isolated from Penicillium sp. Dehydrogriseofulvin inhibits Colletotrichum musae with MIC > 1 µg/scrip.
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Climbazole (Standard)
0 ImagesCat. No.: HY-B1151RCAS No.: 38083-17-9Synonyms: BAY-e 6975 (Standard)Climbazole (Standard) is the analytical standard of Climbazole. This product is intended for research and analytical applications. Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450.
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Cystothiazole A
0 ImagesCat. No.: HY-N14135CAS No.: 207399-36-8Cystothiazole A has antifungal activity. Cystothiazole A can inhibit candida albicans, saccharomyces cerevisiae and aspergillus smoke with MIC values of 0.4 μg/mL, 0.1 μg/mL and 1.6 μg/mL, respectively. Cystothiazole A also inhibits human tumor cell, such as HPT-116 and K562 cells with MIC values of 130 ng/mL and 110 ng/mL, respectively. Cystothiazole A has no anti-bacterial effect.
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Acetylgliotoxin
0 ImagesCat. No.: HY-183421CAS No.: 146016-64-0Synonyms: Gliotoxin monoacetateAcetylgliotoxin (Gliotoxin monoacetate) is a farnesyltransferase (FTase) inhibitor with an IC50 of 4.4 μM against human targets. Acetylgliotoxin inhibits the growth of fungal, bacterial, and viral pathogens; it binds to free protein thiols and induces ROS production. Acetylgliotoxin increases the survival rate of Caenorhabditis elegans infected with Candida albicans, but exhibits toxicity at higher concentrations. Acetylgliotoxin is applicable to research related to Candida albicans infections.
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(Rac)-Lateritin
0 ImagesCat. No.: HY-121407ACAS No.: 2180287-51-6(Rac)-Lateritin is an acyl-CoA:cholesterol acyltransferase (ACAT/SOAT) inhibitor, with IC50 values of 5.7 μM and 5.6 μM in rat liver, respectively. (Rac)-Lateritin exerts time-dependent irreversible enzyme inhibition that persists even after microsomal washing. (Rac)-Lateritin inhibits cholesterol ester formation in macrophages without altering triglyceride synthesis or other steps in oxidized low-density lipoprotein metabolism. (Rac)-Lateritin inhibits the growth of cancer cells, Gram-positive bacteria, and Candida albicans. (Rac)-Lateritin can be used in studies related to atherosclerosis, human solid tumors, mouse lymphocytic leukemia, as well as fungal and bacterial infections.
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4-Isopropylbenzoic acid (Standard)
0 ImagesCat. No.: HY-W013571RCAS No.: 536-66-3Synonyms: Cuminic acid (Standard); p-Isopropyl benzoic acid (Standard)4-Isopropylbenzoic acid (Cuminic acid; p-Isopropyl benzoic acid) an aromatic monoterpenoid, is isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid exhibits antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive inhibitor of mushroom tyrosinase.
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Prolylrapamycin
0 ImagesCat. No.: HY-135445CAS No.: 156223-31-3Synonyms: 21-NorrapamycinProlylrapamycin (21-Norrapamycin) is the derivative of Rapamycin (HY-10219). Prolylrapamycin exhibits antifungal activity, that inhibits Candida albicans, Saccharomyces cerevisiae, and Fusarium oxysporum with MIC of 0.125-2 μg/mL.
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Candicidin (≥50%)
0 ImagesCat. No.: HY-108874ACAS No.: 1403-17-4Synonyms: Levorin (≥50%); Vanobid (≥50%); Candimon (≥50%)Candicidin (≥50%) (Levorin (≥50%)) is an Antifungal antibiotic. Candicidin (≥50%) exhibits potent antifungal activity against yeasts and yeast-like fungi, such as Candida albicans and Saccharomyces cerevisiae. Low concentrations of Candicidin (≥50%) do not adversely affect pea seed germination.
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Antifungal agent 133
0 ImagesCat. No.: HY-176483Antifungal agent 133 (compound D2) is an orally active antifungal agent with a MIC80 of 0.13 ug/mL against C.neoformans H99. Antifungal agent 133 can be used for study of cryptococcal meningitis.
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Fosfluconazole (Standard)
0 ImagesCat. No.: HY-100666RCAS No.: 194798-83-9Fosfluconazole (Standard) is the analytical standard of Fosfluconazole. This product is intended for research and analytical applications. Fosfluconazole is a proagent of Fluconazole that is widely used as an antifungal agent.
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Hyalodendrin
0 ImagesCat. No.: HY-138100CAS No.: 51920-94-6Synonyms: (+)-HyalodendrinHyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice.
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Procymidone (Standard)
0 ImagesCat. No.: HY-B1884RCAS No.: 32809-16-8Procymidone (Standard) is the analytical standard of Procymidone. This product is intended for research and analytical applications. Procymidone, a pesticide, is an immunogen hapten that can be combined with cOVA (carrier protein) to produce polyclonal antibodies. Procymidone has antifungal activity.
