(Rac)-Lateritin
(Rac)-Lateritin is an acyl-CoA:cholesterol acyltransferase (ACAT/SOAT) inhibitor, with IC50 values of 5.7 μM and 5.6 μM in rat liver, respectively. (Rac)-Lateritin exerts time-dependent irreversible enzyme inhibition that persists even after microsomal washing. (Rac)-Lateritin inhibits cholesterol ester formation in macrophages without altering triglyceride synthesis or other steps in oxidized low-density lipoprotein metabolism. (Rac)-Lateritin inhibits the growth of cancer cells, Gram-positive bacteria, and Candida albicans. (Rac)-Lateritin can be used in studies related to atherosclerosis, human solid tumors, mouse lymphocytic leukemia, as well as fungal and bacterial infections.
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- CAS No.: 2180287-51-6
- 화학식: C15H19NO3
- 분자량:261.32
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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ACAT 5.7 μM (IC50) |
SOAT 5.6 μM (IC50) |
(Rac)-Lateritin irreversibly (compound 103) inhibits SOAT activity in rat liver microsomes with an IC50 of 5.6 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2180287-51-6
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분자량 261.32
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화학식 C15H19NO3
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SMILES
O=C1OC(C(=O)N(C)C1CC=2C=CC=CC2)C(C)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Hasumi K, et al. Lateritin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Gibberella lateritium IFO 7188. The Journal of antibiotics. 1993 Dec;46(12):1782-7. [Content Brief]
[2]. Bhattacharjee P, et al. Targeting Sterol -Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential. Journal of medicinal chemistry. 2022 Dec 22;65(24):16062-16098. [Content Brief]
[3]. Pettit RK, et al. Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture. Planta medica. 2010 Mar;76(5):500-1. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-Lateritin Related Classifications
HY-121407A Related Classifications
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