Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2733)
Related Products (2733)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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4-Methylcinnamic acid (Standard)
0 Images4-Methylcinnamic acid, a Cinnamic acid analog, can be used as a intervention catalyst for overcoming antifungal tolerance. 4-Methylcinnamic acid can improve the potency of cell wall-disrupting agents.
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Indole-3-thio carboxamide
0 ImagesIndole-3-thio carboxamide is an antifungal agent. Indole-3-thio carboxamide is a biotransformation product of Camalexin (HY-119502) by plant pathogenic fungi Botrytis cinerea.
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Amisulbrom (Standard)
0 ImagesCat. No.: HY-121214RCAS No.: 348635-87-0Amisulbrom (Standard) is the analytical standard of Amisulbrom (HY-121214). Amisulbrom is a fungicide. Amisulbrom can inhibit the cytochrome-bc1 complex of the mitochondrial electron and induce mitochondrial dysfunction. Amisulbrom can induce cell apoptosis, ROS production and cause G2/M phase arrest. Amisulbrom shows cardiovascular toxicity to zebrafish. Amisulbrom can be used for the researches of infection and cardiovascular disease.
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15-Keto-prostaglandin E2-d4
0 ImagesCat. No.: HY-113205S1CAS No.: 2738376-85-515-Keto-prostaglandin E2-d4 is the d4 labeled 15-keto-Prostaglandin E2 (HY-113205). 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier.
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2-n-Heptyl-4-quinolinol
0 ImagesCat. No.: HY-W572386CAS No.: 2503-80-22-n-Heptyl-4-quinolinol has activity against Candida albicans, Staphylococcus aureus, Vibrio anguillarum and V. Harveyi.
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Naphthomycin B
0 ImagesCat. No.: HY-111264CAS No.: 86825-88-9Naphthomycin B is an antibiotic, which is initially isolated from Streptomyces sp. Naphthomycin B exhibits antimicrobial activities against gram positive bacteria and many fungis.
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Dehydrozingerone (Standard)
0 ImagesDehydrozingerone (Standard) is the analytical standard of Dehydrozingerone. This product is intended for research and analytical applications. Dehydrozingerone (Compound 10), a structural half analogue of Curcumin (HY-N0005), is a phenolic compound with antibacterial, anticancer, antioxidant, anti-Alzheimer’s and antifungal activity, which is isolated from ginger (Zingiber officinale) rhizomes. Dehydrozingerone shows moderate inhibitory activities on the secretion of HBsAg in HepG 2 cells with an IC50 value of 0.50 mM.
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Tolciclate
0 ImagesCat. No.: HY-106546CAS No.: 50838-36-3Synonyms: KC 9147Tolciclate (KC 9147) is an antifungal agent with in vitro inhibitory activity against dermatophytes, effective at concentrations of 0.01-0.1 μg/mL. Tolciclate is colorless and soluble in well-tolerated excipients, and it is more lipophilic than Tolnaftate (HY-B0370). Tolciclate can be used in research related to antifungal infections.
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Neobulgarone F
0 ImagesCat. No.: HY-N14814CAS No.: 315209-20-2Neobulgarone F is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone F can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
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Radulone A
0 ImagesCat. No.: HY-N13024CAS No.: 221374-79-4Radulone A is a secondary metabolite, which can be isolated from the wood decomposing fungus Granulobasidium vellereum. Radulone A inhibits spore germination of Phlebiopsis gigantea, Coniophora puteana and Heterobasidion occidentale, with concentrations of 10 µM, 500 µM and 100 µM, respectively.
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Dactylfungin A
0 ImagesCat. No.: HY-126610CAS No.: 146935-35-5Dactylfungin A, an α-pyrone-containing antifungal agent found in Dactylaria parvispora.
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Thifluzamide (Standard)
0 ImagesCat. No.: HY-B2004RCAS No.: 130000-40-7Thifluzamide (Standard) is the analytical standard of Thifluzamide. This product is intended for research and analytical applications. Thifluzamide is a fungicide that inhibits fungal respiration by blocking the ubiquinone-binding site in mitochondrial complex II. Thifluzamide exhibits significant activity against Basidiomycota pathogens (such as Rhizoctonia cerealis, Ustilago and Puccinia genera) and is commonly used in studies on wheat sharp eyespot. Thifluzamide displays a dual mechanism in regulating lipid metabolism: it reduces fatty acid synthase activity to inhibit endogenous fatty acid synthesis, and increases carnitine palmitoyltransferase-I activity to accelerate fatty acid β-oxidation, thereby reducing total cholesterol and triglyceride levels in the liver. Thifluzamide also induces hepatotoxicity in zebrafish models and carries a risk of developmental toxicity. Thifluzamide inhibition of Rhizoctonia cerealis may result in low to moderate levels of drug resistance, leading to the generation of stable drug-resistant mutants.
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CYP51-IN-4
0 ImagesCat. No.: HY-136754CAS No.: 1155361-02-6CYP51-IN-2 (compound 1d), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 15.6 ng/mL for Microsporum gypseum and Candida albicans.
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Mycoversilin
0 ImagesCat. No.: HY-N14409CAS No.: 88527-18-8Mycoversilin is an antibiotic. Mycoversilin has the activity of inhibiting skin fungi and phytopathogenic fungi, but has no anti-yeast and bacterial activity. Mycoversilin has a strong inhibitory effect on protein synthesis.
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Famoxadone (Standard)
0 ImagesSynonyms: DPX-JE874 (Standard)Famoxadone (Standard) is the analytical standard of Famoxadone. This product is intended for research and analytical applications. Famoxadone is a fungicide active against various oomycetes. Famoxadone induces rapid lysis of zoospores of P. viticola and P. infestans, and inhibits sporangial differentiation, zoospore release, sporangial germination and mycelial growth. Famoxadone exerts a preventive control effect on plant diseases. Famoxadone can be used in research related to grape downy mildew, potato late blight, tomato late blight and plant oomycete diseases.
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Chivosazol A
0 ImagesCat. No.: HY-N15057CAS No.: 169181-40-2Chivosazol A has anti-yeast and filamentous fungal activity and has strong toxicity to mammalian cells.
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Enactin Ⅰb
0 ImagesCat. No.: HY-N14878CAS No.: 137252-26-7Enactin Ib is found in the strain of Streptomyces roseoviridis. Enactin Ib has only weak antifungal activity.
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Glidobactin A
0 ImagesCat. No.: HY-N14018CAS No.: 108351-50-4Glidobactin A is an acyl peptide antibiotic. Glidobactin A has activity against Candida, Aspergillus fumigatus and Trichophyton, but it is not effective against Candida albicans M-9 infection in mice.
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710674-S
0 ImagesCat. No.: HY-W791931CAS No.: 77174-66-4710674-S is a synthetic imidazole derivative with antibacterial and antifungal activities. 710674-S exhibits potent activity against dermatophytes, and moderate activity against Candida species, other yeasts, Gram-positive aerobic bacteria and most anaerobic bacteria. 710674-S inhibits lanosterol 14α-demethylase (CYP51), a key enzyme in the fungal ergosterol biosynthetic pathway. The antifungal activity of 710674-S increases in alkaline culture media. 710674-S can be used in studies related to fungal infectious diseases.
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Terbinafine-d3
0 ImagesCat. No.: HY-17395AS1CAS No.: 1133210-36-2Synonyms: TDT 067-d3Terbinafine-d3 (TDT 067-d3) is deuterium labeled Terbinafine. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
