1080-12-2
Chemical Structure
Dehydrozingerone
- CAS No.: 1080-12-2
- Formula:C11H12O3
- Molecular Weight:192.21
IUPAC Name: (E)-4-(4-hydroxy-3-methoxyphenyl)but-3-en-2-one
InChIKey: AFWKBSMFXWNGRE-ONEGZZNKSA-N
SMILES: CC(/C=C/C1=CC=C(O)C(OC)=C1)=O
Biological Activity: Dehydrozingerone is a ginger-derived component and cyclin D1 inhibitor that downregulates cyclin D1 expression and induces cell cycle G1 phase arrest. Dehydrozingerone reduces the proliferative capacity of castration-resistant prostate cancer cells under in vitro conditions. Dehydrozingerone reduces subcutaneous tumor growth by inhibiting cell proliferation and angiogenesis. Dehydrozingerone exerts antibacterial and antifungal activities via its α,β-unsaturated carbonyl conjugated system. Dehydrozingerone can be used in studies related to castration-resistant prostate cancer, bacterial infections, and food spoilage fungal infections[1][2][3].
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Dehydrozingerone | 99.98% | Dehydrozingerone is a ginger-derived component and cyclin D1 inhibitor that downregulates cyclin D1 expression and induces cell cycle G1 phase arrest. Dehydrozingerone reduces the proliferative capacity of castration-resistant prostate cancer cells under in vitro conditions. Dehydrozingerone reduces subcutaneous tumor growth by inhibiting cell proliferation and angiogenesis. Dehydrozingerone exerts antibacterial and antifungal activities via its α,β-unsaturated carbonyl conjugated system. Dehydrozingerone can be used in studies related to castration-resistant prostate cancer, bacterial infections, and food spoilage fungal infections. | ||||||||||||||||||||
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Dehydrozingerone (Standard) | 99.96% | Dehydrozingerone (Standard) is the analytical standard of Dehydrozingerone. This product is intended for research and analytical applications. Dehydrozingerone (Compound 10), a structural half analogue of Curcumin (HY-N0005), is a phenolic compound with antibacterial, anticancer, antioxidant, anti-Alzheimer’s and antifungal activity, which is isolated from ginger (Zingiber officinale) rhizomes. Dehydrozingerone shows moderate inhibitory activities on the secretion of HBsAg in HepG 2 cells with an IC50 value of 0.50 mM. | ||||||||||||||||||||
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References
- [1]. Mapoung S, et al. Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo. Molecules. 2020;25(12):2737. Published 2020 Jun 12. [Content Brief]
- [2]. Kubra IR, et al. Structure-function activity of dehydrozingerone and its derivatives as antioxidant and antimicrobial compounds. J Food Sci Technol. 2014;51(2):245-255. [Content Brief]
- [3]. Kubra IR, et al. In vitro antifungal activity of dehydrozingerone and its fungitoxic properties. J Food Sci. 2013;78(1):M64-M69. [Content Brief]
