Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2737)
Related Products (2737)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Antibacterial agent 225
0 ImagesCat. No.: HY-162615CAS No.: 3047459-82-2Antibacterial agent 225 (compound 12a-2) simultaneously exerts excellent bifunctional effects of fungal inhibition and immune activation.
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Benz[g]isoquinoline-5,10-dione
![Benz[g]isoquinoline-5,10-dione](https://file.medchemexpress.com/product_pic/hy-w320538.gif "Click to View Benz[g]isoquinoline-5,10-dione Product Detail")
0 ImagesCat. No.: HY-W320538CAS No.: 46492-08-4Benz[g]isoquinoline-5,10-dione, an active component isolated from the ethanolic extract of the aerial parts of Mitracarpus scaber, demonstrates notable in vitro inhibitory activity against AIDS-related pathogens, along with significant antibacterial and antifungal properties, as evidenced by the agar well-diffusion assay.
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Amisulbrom
0 ImagesAmisulbrom is a sulfonamide fungicide used to control oomycete diseases. Amisulbrom inhibits the cytochrome-bc1 complex of the mitochondrial electron transport system.
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Mathemycin A
0 ImagesCat. No.: HY-N14195CAS No.: 211374-76-4Mathemycin A has an inhibitory effect on pathogenic fungi. Mathemycin A inhibits the Phytophthora infestans JO8 in vitro (MIC is 7.8 μg/mL), and it inhibits JO8 in greenhouse (LD50 is 42 X 10-6, LC90 is 500 X 10-6).
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Melithiazole A
0 ImagesCat. No.: HY-N14248CAS No.: 170894-30-1Melithiazol A is an antibiotic. Melithiazole A is a β-methoxyacrylate (MOA) inhibitor with strong anti-agent activity. Antifungal and cytotoxic agent.
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Terbinafine hydrochloride (Standard)
0 ImagesSynonyms: TDT 067 hydrochloride (Standard)Terbinafine hydrochloride (Standard) is the analytical standard of Terbinafine hydrochloride. This product is intended for research and analytical applications. Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Clavamycin D
0 ImagesCat. No.: HY-N13999CAS No.: 103059-95-6Clavamycin D has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase.
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Isolubimin
0 ImagesCat. No.: HY-171795CAS No.: 60077-68-1Isolubimin is a sesquiterpenoid phytoalexin found in Datura stramonium fruits with antibacterial activity. Isolubimin is promising for research of plant disease caused by fungal infections.
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Lanoconazole (Standard)
0 ImagesCat. No.: HY-14282RCAS No.: 101530-10-3Lanoconazole (Standard) is the analytical standard of Lanoconazole. This product is intended for research and analytical applications. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.
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Antifungal agent 151
0 ImagesCat. No.: HY-181101CAS No.: 3097563-43-1Antifungal agent 151 is a Prp8 intein inhibitor that inhibits the self-splicing process of the Prp8 intein, preventing maturation of the Prp8 protein. Antifungal agent 151 exerts in vitro antifungal activity against Cryptococcus neoformans and Cryptococcus gattii. Antifungal agent 151 can be used for the research of cryptococcus pneumonia.
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Sclerodione
0 ImagesCat. No.: HY-N12893CAS No.: 104855-19-8Sclerodione is a metabolite that can be produced by the Scleroderris canker fungus, Gremmeniellaabietina. Sclerodione has antifungal activity. Sclerodione is a lipase inhibitor (IC50: 1 μM).
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Kanchanamycin C
0 ImagesCat. No.: HY-N14857CAS No.: 163565-45-5Kanchanamycin C has anti-Gram positive and negative bacteria, yeast and filamentous fungus action.
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Pentamidine (Standard)
0 ImagesPentamidine (Standard) is the analytical standard of Pentamidine. This product is intended for research and analytical applications. Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.
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Aminopyrifen
0 ImagesAminopyrifen is a GWT-1 inhibitor. Aminopyrifen inhibits the inositol acylation of phosphatidylinositol, disrupting the maturation process of GPI-anchored proteins and the integrity of fungal cell walls. Aminopyrifen strongly inhibits germ tube elongation of Botrytis cinerea, delays spore germination, prevents appressorium formation, and blocks the infection of plant tissues by pathogenic fungi. Aminopyrifen is effective against field populations of eggplant gray mold and cucumber powdery mildew, and can be used for research on various plant fungal diseases such as gray mold and powdery mildew.
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Cladosporide D
0 ImagesCat. No.: HY-N14124CAS No.: 376368-83-1Cladosporide D is found in the strain of Cladosporium sp. IFM 49191. Cladosporide D has no antifungal activity.
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Pirtenidine free base
0 ImagesCat. No.: HY-111989CAS No.: 103923-27-9Pirtenidine free base is a broad-spectrum antibacterial and anti-plaque agent. Pirtenidine free base exhibits bactericidal activity against oral plaque bacteria in vitro and inhibits plaque formation. Pirtenidine free base inhibits the growth, budding, germ tube formation and buccal epithelial cell adhesion of Candida albicans and Saccharomyces cerevisiae, reduces the oxygen uptake rate of yeast, and impairs mitochondrial respiratory function. Pirtenidine free base disrupts the integrity of fungal cell wall and membrane, leading to cytoplasmic leakage, cell shrinkage, and lysis. Pirtenidine free base binds tightly to mucosal surfaces in vivo with low systemic exposure. Pirtenidine free base can be used in studies related to dental plaque, fungal infections and oral candidiasis.
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Furalaxyl (Standard)
0 ImagesCat. No.: HY-118578RCAS No.: 57646-30-7Synonyms: CGA 38140 (Standard)Furalaxyl (Standard) is the analytical standard of Furalaxyl. This product is intended for research and analytical applications. Furalaxyl (CGA 38140) is a potent fungicide. Furalaxyl is highly selective to fungi of the order of the Peronosporales.
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6-Prenylindole
0 ImagesCat. No.: HY-138223CAS No.: 23158-16-96-Prenylindole is an antifungal agent that can be isolated from Streptomyces.
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Antifungal agent-167
0 ImagesCat. No.: HY-184286CAS No.: 3116899-76-1Antifungal agent-167 is an Antifungal agent. Antifungal agent-167 promotes the release of cellular contents and impairs the permeability of fungal cell membranes. Antifungal agent-167 exhibits antifungal activity against Gaeumannomyces graminis and Colletotrichum orbiculare, with a EC50 of 34.1 μg/mL against Colletotrichum orbiculare. Antifungal agent-167 can be used in studies related to Colletotrichum orbiculare infection.
