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Cat. No.: HY-184286

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Antifungal agent-167

Antifungal agent-167 is an Antifungal agent. Antifungal agent-167 promotes the release of cellular contents and impairs the permeability of fungal cell membranes. Antifungal agent-167 exhibits antifungal activity against Gaeumannomyces graminis and Colletotrichum orbiculare, with a EC₅₀ of 34.1 μg/mL against Colletotrichum orbiculare. Antifungal agent-167 can be used in studies related to Colletotrichum orbiculare infection.

For research use only. We do not sell to patients.

CAS No.: 3116899-76-1
Formula: C₁₅H₁₉NO₅
Molecular Weight:293.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antifungal agent-167 Chemical Structure

CAS No.: 3116899-76-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Antifungal agent-167 (Compound 3n) (7.5-120 μg/mL; 72 h) potently inhibits Colletotrichum orbiculare mycelium growth in vitro with an EC₅₀ of 34.1 μg/mL and a 60.9% inhibition rate at 50 μg/mL^[1].
Antifungal agent-167 (50 μg/mL; 72 h) inhibits Gaeumannomyces graminis mycelium growth in vitro with a 63.6% inhibition rate at 50 μg/mL^[1].
Antifungal agent-167 (15-60 μg/mL) increases cytoplasmic content release from Colletotrichum orbiculare mycelia in a concentration-dependent manner, damaging fungal cell membrane permeability^[1].
Antifungal agent-167 (15-30 μg/mL) exhibits moderate cytotoxicity to normal LO2 liver cells, with a cell survival rate of ~50% at 30 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3116899-76-1
Molecular Weight 293.32
Formula C₁₅H₁₉NO₅
SMILES

OC1=CC(OCO2)=C2C=C1C(C(C)CN3CCOCC3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sui G, et al. Utilization of natural product for developing promising sterol biosynthesis inhibitors: design, synthesis and antifungal evaluation of cyclic trialkylamine derivatives. Bioorganic chemistry. 2026 Jun 08;180:110079. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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