103923-27-9
Chemical Structure
Pirtenidine free base
- CAS No.: 103923-27-9
- Formula:C21H38N2
- Molecular Weight:318.55
IUPAC Name: N,1-dioctylpyridin-4(1H)-imine
InChIKey: RGTPDNXJDCPXAB-UHFFFAOYSA-N
SMILES: N(=C1C=CN(C=C1)CCCCCCCC)CCCCCCCC
Biological Activity: Pirtenidine free base is a broad-spectrum antibacterial and anti-plaque agent. Pirtenidine free base exhibits bactericidal activity against oral plaque bacteria in vitro and inhibits plaque formation. Pirtenidine free base inhibits the growth, budding, germ tube formation and buccal epithelial cell adhesion of Candida albicans and Saccharomyces cerevisiae, reduces the oxygen uptake rate of yeast, and impairs mitochondrial respiratory function. Pirtenidine free base disrupts the integrity of fungal cell wall and membrane, leading to cytoplasmic leakage, cell shrinkage, and lysis. Pirtenidine free base binds tightly to mucosal surfaces in vivo with low systemic exposure. Pirtenidine free base can be used in studies related to dental plaque, fungal infections and oral candidiasis[1][2][3][4][5].
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Pirtenidine free base | Pirtenidine free base is a broad-spectrum antibacterial and anti-plaque agent. Pirtenidine free base exhibits bactericidal activity against oral plaque bacteria in vitro and inhibits plaque formation. Pirtenidine free base inhibits the growth, budding, germ tube formation and buccal epithelial cell adhesion of Candida albicans and Saccharomyces cerevisiae, reduces the oxygen uptake rate of yeast, and impairs mitochondrial respiratory function. Pirtenidine free base disrupts the integrity of fungal cell wall and membrane, leading to cytoplasmic leakage, cell shrinkage, and lysis. Pirtenidine free base binds tightly to mucosal surfaces in vivo with low systemic exposure. Pirtenidine free base can be used in studies related to dental plaque, fungal infections and oral candidiasis. | |||||||||||||||||||||
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References
- [1]. Wentland MP, et al. The in vitro dental plaque inhibitory properties of a series of N-[1-alkyl-4(1H)-pyridinylidene]alkylamines. Journal of medicinal chemistry. 1988 Oct;31(10):2024-7.
- [2]. Ghannoum MA, et al. Antimycotic effects of octenidine and pirtenidine. The Journal of antimicrobial chemotherapy. 1990 Feb;25(2):237-45.
- [3]. Ghannoum MA, et al. Effects of octenidine and pirtenidine on adhesion of Candida species to human buccal epithelial cells in vitro. Archives of oral biology. 1990;35(4):249-53.
- [4]. Powles P, et al. The pharmacokinetics of pirtenidine in the rat and dog. Xenobiotica; the fate of foreign compounds in biological systems. 1989 Dec;19(12):1349-54.
- [5]. Ellabib M, et al. Effects of the pyridinamines octenidine and pirtenidine on yeast mitochondrial function. Biochem Soc Trans. 1990 Apr;18(2):342-3.
