68053-32-7
Chemical Structure
Merulidial
Synonym(s): (-)-Merulidial
- CAS No.: 68053-32-7
- Formula:C15H20O3
- Molecular Weight:248.32
SMILES: O=C[C@@]12[C@@](C1)([C@H]([C@@]3([H])C(CC(C)(C3)C)=C2C=O)O)C
Biological Activity: Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum). Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC50 s of 20 and 10 μg/mL for ECA and L1210 cells, respectively [1][2][3].
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Merulidial | Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum). Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC50 s of 20 and 10 μg/mL for ECA and L1210 cells, respectively . | |||||||||||||||||||||
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- [1]. 1. Svensson M, et al. Pyrone and pyridone compounds in the liquid culture of Physisporinus sanguinolentus. Phytochemistry. 2001 Apr; 56(7):747-51. [Content Brief]
- [2]. 2. Quack W, et al. Antibiotics from Basidiomycetes. V merulidial, a new antibiotic from the Basidiomycete Merulius tremellosus Fr. J Antibiot (Tokyo). 1978 Aug; 31(8):737-41. [Content Brief]
- [3]. 3. Anke H, et al. Structure-activity relationships for unsaturated dialdehydes. 3. Mutagenic, antimicrobial, cytotoxic, and phytotoxic activities of merulidial derivatives. J Antibiot (Tokyo). 1989 May; 42(5):738-44. [Content Brief]
Keywords
