Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2719)
Related Products (2719)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Isavuconazonium sulfate (Standard)
0 ImagesCat. No.: HY-100373RCAS No.: 946075-13-4Synonyms: BAL8557-002 (Standard)Isavuconazonium (sulfate) (Standard) is the analytical standard of Isavuconazonium (sulfate) (HY-100373). This product is intended for research and analytical applications. Isavuconazonium sulfate (BAL8557-002) is an orally active broad-spectrum antifungal molecule. Isavuconazonium sulfate is a precursor of the triazole antifungal active molecule Isavuconazole. Isavuconazonium sulfate can be used in the study of invasive aspergillosis, mucormycosis, blastomycosis, and Acanthamoeba keratitis.
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Lepiochlorin
0 ImagesCat. No.: HY-121395CAS No.: 71339-41-8Lepiochlorin is an antibiotic metabolite produced by a fungus (Lepiota species) that is cultivated by ants, which can prevent fungal contamination.
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Aselacin C
0 ImagesCat. No.: HY-N15183CAS No.: 156223-08-4Aselacin C is a cyclic peptide that can be isolated from the fungus Acremonium spp..
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Polyoxin L
0 ImagesCat. No.: HY-N14216CAS No.: 22976-90-5Polyoxin L is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
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Penthiopyrad (Standard)
0 ImagesCat. No.: HY-17520RCAS No.: 183675-82-3Synonyms: MTF-753 (Standard)Penthiopyrad (Standard) is the analytical standard of Penthiopyrad. This product is intended for research and analytical applications. Penthiopyrad (MTF-753) is a chiral carboxamide antifungal agent with a broad spectrum of fungicidal activity. Penthiopyrad can be used for controlling foliar and soil-borne plants diseases on a broad range of agricultural crops and turfgrass.
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Ravuconazole-d4
0 ImagesCat. No.: HY-14272SCAS No.: 1329499-27-5Ravuconazole-d4 is the deuterium labeled Ravuconazole. Ravuconazole (BMS-207147) is an orally available triazoleantifungle agent that potently inhibits a wide range of fungi.
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Acremine I
0 ImagesCat. No.: HY-N8511CAS No.: 1110661-29-4Acremine I is a fungi inhibitor and also a metabolite of the endophytic fungus Acremonium byssoides. Acremine I can effectively inhibit Plasmopara viticola. Acremine I can be used for research on plant diseases, such as grape downy mildew.
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Kalafungin
0 ImagesCat. No.: HY-105751CAS No.: 11048-15-0Synonyms: Kalamycin; U-19718Kalafungin is an antibiotic, antimicrobial agent and a β-lactamase inhibitor from marine Streptomyces, with IC50 of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria.
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Epoxiconazole (Standard)
0 ImagesEpoxiconazole (Standard) is the analytical standard of Epoxiconazole. This product is intended for research and analytical applications. Epoxiconazole, a fungicide, is a demethylation inhibitor of the Ergosterol biosynthesis pathway. Epoxiconazole exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates, and can be used for controlling many crop diseases.
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Polyoxin M
0 ImagesCat. No.: HY-N15107CAS No.: 34718-88-2Polyoxin M is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
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N,O-Diacetyltyramine
0 ImagesCat. No.: HY-138210CAS No.: 14383-56-3N,O-Diacetyltyramine is a compound with antibacterial activity and cytotoxicity that can be isolated from the actinomycete Pseudonocardia endophytica VUK-10. N,O-Diacetyltyramine has antibacterial activity against Gram-positive and Gram-negative bacteria and fungi. N,O-Diacetyltyramine is cytotoxic to MDA-MB-231, HeLa, MCF-7 and OAW-42 cells.
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SDH-IN-42
0 ImagesCat. No.: HY-179287SDH-IN-42 (Compound D28) is a SDH (IC50: 5.38 μg/mL) inhibitor and antifungal agent. SDH-IN-42 exerts antifungal activity against R. solani by disrupting mycelial morphology, increasing cell membrane permeability, inducing the production and accumulation of ROS, and impairing mitochondrial function.
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NSC145366 monohydrochloride
0 ImagesCat. No.: HY-117192CAS No.: 1052515-37-3
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Chondramide D
0 ImagesCat. No.: HY-N14054CAS No.: 172430-63-6Chondramide D has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities.
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Imazalil sulfate
0 ImagesSynonyms: Enilconazolel sulfateImazalil (Enilconazole) sulfate is a fungicide. Imazalil sulfate has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil sulfate is commonly used to protect various agricultural crops against fungal attack. Imazalil sulfate induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder.
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Crocacin C
0 ImagesCat. No.: HY-N14043CAS No.: 237425-38-6Crocacin C has anti-yeast and filamentous fungal activity. Crocacin C can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin C can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum.
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MoTPS1/2-IN-1
0 ImagesCat. No.: HY-157446MoTPS1/2-IN-1 (Compound A1-4 ) is a bispecific inhibitor of MoTps1 and MoTps2. MoTPS1/2-IN-1 has antifungal activity and showed good inhibitory activity against the growth and virulence of B. cinerea and F. graminearum.
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Mollugogenol A
0 ImagesCat. No.: HY-135438CAS No.: 22550-76-1Mollugogenol A is a fungal inhibitor. Mollugogenol A can cause damage to sperm membranes by increasing lipid peroxidation, exhibiting sperm-killing activity.
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SDH-IN-41
0 ImagesCat. No.: HY-179296SDH-IN-41 (Compound 3d-1) is an antifungal agent, SDH inhibitor, with an IC50 value of 4.14 mg/L against SsSDH. SDH-IN-41 shows antifungal activity against S. sclerotiorum with an EC50 value of 1.86 mg/L.
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Hydranthomycin
0 ImagesCat. No.: HY-N14324CAS No.: 172923-86-3Hydranthomycin is an antibiotic. Hydranthomycin has moderate antifungal activity, and the MIC of Pyricularia oryzae is 25 μg/mL. Hydranthomycin inhibits the growth of Euglena gracilis and has herbicidal activity.
