1. Anti-infection
  2. Fungal
  3. Isavuconazonium sulfate

Isavuconazonium sulfate (Synonyms: BAL8557-002)

Cat. No.: HY-100373
Handling Instructions

Isavuconazonium sulfate (BAL8557-002), the prodrug of the active triazole Isavuconazole, is an orally active antifungal agent. Isavuconazonium sulfate is used for invasive aspergillosis and mucormycosis.

For research use only. We do not sell to patients.

Isavuconazonium sulfate Chemical Structure

Isavuconazonium sulfate Chemical Structure

CAS No. : 946075-13-4

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Description

Isavuconazonium sulfate (BAL8557-002), the prodrug of the active triazole Isavuconazole, is an orally active antifungal agent. Isavuconazonium sulfate is used for invasive aspergillosis and mucormycosis[1][2].

Clinical Trial
Molecular Weight

814.84

Formula

C₃₅H₃₆F₂N₈O₉S₂

CAS No.

946075-13-4

SMILES

O[[email protected]@](CN(N=C1)C=[N+]1C(C)OC(N(C(N=CC=C2)=C2COC(CNC)=O)C)=O)(C(C=C3F)=C(C=C3)F)[[email protected]](C4=NC(C(C=C5)=CC=C5C#N)=CS4)C.O=[S]([O-])(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 166.67 mg/mL (204.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2272 mL 6.1362 mL 12.2723 mL
5 mM 0.2454 mL 1.2272 mL 2.4545 mL
10 mM 0.1227 mL 0.6136 mL 1.2272 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.55 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (2.55 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.55 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

IsavuconazoniumBAL8557-002FungalprodrugantifungalinvasiveaspergillosismucormycosisfungalinfectionsInhibitorinhibitorinhibit

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Product Name:
Isavuconazonium sulfate
Cat. No.:
HY-100373
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