2. Anti-infection
  3. Fungal
  4. Isavuconazonium sulfate

Isavuconazonium sulfate  (Synonyms: BAL8557-002)

Cat. No.: HY-100373 Purity: 98.53%
COA Handling Instructions

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Isavuconazonium sulfate (BAL8557-002) is an orally active broad-spectrum antifungal molecule. Isavuconazonium sulfate is a precursor of the triazole antifungal active molecule Isavuconazole. Isavuconazonium sulfate can be used in the study of invasive aspergillosis, mucormycosis, blastomycosis, and Acanthamoeba keratitis.

For research use only. We do not sell to patients.

Isavuconazonium sulfate Chemical Structure

Isavuconazonium sulfate Chemical Structure

CAS No. : 946075-13-4

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Based on 1 publication(s) in Google Scholar

Isavuconazonium sulfate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Isavuconazonium sulfate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Isavuconazonium sulfate (BAL8557-002) is an orally active broad-spectrum antifungal molecule. Isavuconazonium sulfate is a precursor of the triazole antifungal active molecule Isavuconazole. Isavuconazonium sulfate can be used in the study of invasive aspergillosis, mucormycosis, blastomycosis, and Acanthamoeba keratitis[1][2][3][4][5].

In Vitro

Isavuconazonium sulfate (0.006 nM-50 μM) inhibits trophoblast activity of three T4-genotype strains of Acanthamoeba (Ma, CDC:V240 and MEEI 0184) with EC50 vaules of 0.001 μM, 0.037 μM and 0.024 μM, respectively. And (100-200 μM; 48 h) has vesicle-extinguishing activity in three tested strains Ma, CDC:V240, and MEEI 0184 with mean minimum vesicle extinguishing concentration (MCC) of 167.1 μM, 136.0 μM, and 187.5 μM, respectively[2].
Isavuconazonium sulfate inhibits bacteria with minimum inhibitory concentration (MIC) < 0.015 μg/mL[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isavuconazonium sulfate Related Antibodies
In Vivo

Isavuconazonium sulfate (215 mg/kg; p.o.; Three times a day for 4 days) has anti-R.delemar virus activity in ICR mice infected with mucormycosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Neutropenic male ICR mouse model of intratracheal infection[4]
Dosage: 215 mg/kg
Administration: Oral gavage (p.o.); Three times a day for 4 days.
Result: Increased the survival rate of neutropenic mice infected with R. delemar.
Reduced fungal load in the lungs and brains of mice.
Clinical Trial
Molecular Weight

814.84

Formula

C35H36F2N8O9S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@](CN(N=C1)C=[N+]1C(C)OC(N(C(N=CC=C2)=C2COC(CNC)=O)C)=O)(C(C=C3F)=C(C=C3)F)[C@H](C4=NC(C(C=C5)=CC=C5C#N)=CS4)C.O=[S]([O-])(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (122.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.5 mg/mL (0.61 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2272 mL 6.1362 mL 12.2723 mL
5 mM 0.2454 mL 1.2272 mL 2.4545 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (2.55 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (2.55 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (122.72 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 98.53%

COA (254 KB) HNMR (355 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2272 mL 6.1362 mL 12.2723 mL 30.6809 mL
5 mM 0.2454 mL 1.2272 mL 2.4545 mL 6.1362 mL
10 mM 0.1227 mL 0.6136 mL 1.2272 mL 3.0681 mL
15 mM 0.0818 mL 0.4091 mL 0.8182 mL 2.0454 mL
20 mM 0.0614 mL 0.3068 mL 0.6136 mL 1.5340 mL
25 mM 0.0491 mL 0.2454 mL 0.4909 mL 1.2272 mL
30 mM 0.0409 mL 0.2045 mL 0.4091 mL 1.0227 mL
40 mM 0.0307 mL 0.1534 mL 0.3068 mL 0.7670 mL
50 mM 0.0245 mL 0.1227 mL 0.2454 mL 0.6136 mL
60 mM 0.0205 mL 0.1023 mL 0.2045 mL 0.5113 mL
80 mM 0.0153 mL 0.0767 mL 0.1534 mL 0.3835 mL
100 mM 0.0123 mL 0.0614 mL 0.1227 mL 0.3068 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Isavuconazonium sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isavuconazonium946075-13-4BAL8557-002FungalBlastomyces dermatitidisBlastomycosisAcanthamoeba keratitisInvasive AspergillosisInvasive MucormycosisBacteriostatfungalinfectionsMaCDC:V240MEEI 0184Inhibitorinhibitorinhibit

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