NSC145366 monohydrochloride
NSC145366 monohydrochloride is a Hsp90 C-terminal inhibitor. NSC145366 monohydrochloride directly interacts with the C-terminus of Hsp90 and inhibits its chaperone activity. NSC145366 monohydrochloride strongly inhibits the growth of Saccharomyces cerevisiae cog7Δ and cog8Δ strains.
For research use only. We do not sell to patients.
- CAS No.: 1052515-37-3
- Formula: C37H63ClN2O4
- Molecular Weight:635.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HSP90 |
NSC145366 monohydrochloride (20-100 μM; 0-60 h) inhibits the growth of S. cerevisiae cog7Δ and cog8Δ strains, and induces selective sensitivity in ras2Δ strains[1].
NSC145366 monohydrochloride (500 μM; 2 h) directly binds to Hsp90 in MDA-MB-468 cell lysates[1].
NSC145366 monohydrochloride (10-40 μM; 60 min) dose-dependently inhibits the intrinsic chaperone activity of the recombinant Hsp90α C-terminal domain[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1052515-37-3
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Molecular Weight 635.36
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Formula C37H63ClN2O4
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SMILES
OC(CNC(C)(CC(C)(C)C)C)COC1=CC=C(C(C)(C)C2=CC=C(C=C2)OCC(CNC(C)(CC(C)(C)C)C)O)C=C1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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