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  3. HSP Fungal
  4. NSC145366 monohydrochloride

NSC145366 monohydrochloride is a Hsp90 C-terminal inhibitor. NSC145366 monohydrochloride directly interacts with the C-terminus of Hsp90 and inhibits its chaperone activity. NSC145366 monohydrochloride strongly inhibits the growth of Saccharomyces cerevisiae cog7Δ and cog8Δ strains.

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NSC145366 monohydrochloride

NSC145366 monohydrochloride Chemical Structure

CAS No. : 1052515-37-3

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NSC145366 monohydrochloride Related Antibodies

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Description

NSC145366 monohydrochloride is a Hsp90 C-terminal inhibitor. NSC145366 monohydrochloride directly interacts with the C-terminus of Hsp90 and inhibits its chaperone activity. NSC145366 monohydrochloride strongly inhibits the growth of Saccharomyces cerevisiae cog7Δ and cog8Δ strains[1].

IC50 & Target[1]

HSP90

 

In Vitro

NSC145366 monohydrochloride (20-100 μM; 0-60 h) inhibits the growth of S. cerevisiae cog7Δ and cog8Δ strains, and induces selective sensitivity in ras2Δ strains[1].
NSC145366 monohydrochloride (500 μM; 2 h) directly binds to Hsp90 in MDA-MB-468 cell lysates[1].
NSC145366 monohydrochloride (10-40 μM; 60 min) dose-dependently inhibits the intrinsic chaperone activity of the recombinant Hsp90α C-terminal domain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC145366 monohydrochloride Related Antibodies
Molecular Weight

635.36

Formula

C37H63ClN2O4
CAS No.
SMILES

OC(CNC(C)(CC(C)(C)C)C)COC1=CC=C(C(C)(C)C2=CC=C(C=C2)OCC(CNC(C)(CC(C)(C)C)C)O)C=C1.Cl
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Room temperature in continental US; may vary elsewhere.
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References
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NSC145366 monohydrochloride Related Classifications

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Keywords:

NSC145366 monohydrochloride1052515-37-3HSPFungalHeat shock proteinsHsp90C-terminal domainMDA-MB-468Inhibitorinhibitorinhibit

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