1052515-37-3
1052515-37-3
Chemical Structure
NSC145366 monohydrochloride
- CAS No.: 1052515-37-3
- Formula:C37H63ClN2O4
- Molecular Weight:635.36
IUPAC Name: 3,3'-((propane-2,2-diylbis(4,1-phenylene))bis(oxy))bis(1-((2,4,4-trimethylpentan-2-yl)amino)propan-2-ol) hydrochloride
InChIKey: ZEBSJHGFNKTDIN-UHFFFAOYSA-N
SMILES: OC(CNC(C)(CC(C)(C)C)C)COC1=CC=C(C(C)(C)C2=CC=C(C=C2)OCC(CNC(C)(CC(C)(C)C)C)O)C=C1.Cl
Biological Activity: NSC145366 monohydrochloride is a Hsp90 C-terminal inhibitor. NSC145366 monohydrochloride directly interacts with the C-terminus of Hsp90 and inhibits its chaperone activity. NSC145366 monohydrochloride strongly inhibits the growth of Saccharomyces cerevisiae cog7Δ and cog8Δ strains[1].
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NSC145366 monohydrochloride | NSC145366 monohydrochloride is a Hsp90 C-terminal inhibitor. NSC145366 monohydrochloride directly interacts with the C-terminus of Hsp90 and inhibits its chaperone activity. NSC145366 monohydrochloride strongly inhibits the growth of Saccharomyces cerevisiae cog7Δ and cog8Δ strains. | |||||||||||||||||||||
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