PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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Propargyl-PEG5-acid
0 ImagesPropargyl-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG5-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Thiol-PEG4-NH2 hydrochloride
0 ImagesCat. No.: HY-138446CAS No.: 2762393-21-3Synonyms: SH-PEG4-NH2 hydrochloride
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tert-Butyl 5-bromoisoindoline-2-carboxylate
0 ImagesSynonyms: Tert-butyl 5-bromo-1,3-dihydro-2H-isoindole-2- carboxylatetert-Butyl 5-bromoisoindoline-2-carboxylate (Tert-butyl 5-bromo-1,3-dihydro-2H-isoindole-2- carboxylate) is a PROTAC Linker. tert-Butyl 5-bromoisoindoline-2-carboxylate can be used in synthesis PTOTAC HSD17B13 degrader 1 (HY-159651).
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Tos-PEG2-NH-Boc
0 ImagesCat. No.: HY-135798CAS No.: 192132-77-7
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Bromo-PEG6-alcohol
0 ImagesCat. No.: HY-141215CAS No.: 136399-05-8
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22-(tert-Butoxy)-22-oxodocosanoic acid
0 Images22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t
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Bis-PEG8-acid
0 ImagesCat. No.: HY-126893CAS No.: 1246189-43-4Bis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Fluorescein-PEG3-amine
0 ImagesCat. No.: HY-141080CAS No.: 1807539-04-3
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DBCO-PEG9-amine TFA
0 ImagesCat. No.: HY-140285A
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H-cis-Hyp-OMe hydrochloride
0 ImagesH-cis-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-cis-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR
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2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid
0 ImagesCat. No.: HY-43048CAS No.: 2231744-57-1
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N-(Azido-PEG4)-N-Boc-PEG4-NHS ester
0 ImagesCat. No.: HY-130312CAS No.: 2112731-96-9N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is a PEG-based PROTAC linker with a terminal azide group. N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is used in the synthesis of PROTACs N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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NHS-PEG1-SS-PEG1-NHS
0 ImagesNHS-PEG1-SS-PEG1-NHS is a reversible linker for biomacromolecule link with active small molecule. NHS-PEG1-SS-PEG1-NHS can be used in proteins liposomes or nanoparticles.
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Mal-PEG1-acid
0 ImagesMal-PEG1-acid is is a non-cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
