Thiol-PEG4-NH2 hydrochloride
Based on 1 Customer Validation
Thiol-PEG4-NH2 hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 2762393-21-3
- Formula: C10H24ClNO4S
- Molecular Weight:289.82
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2762393-21-3
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Appearance Liquid
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Molecular Weight 289.82
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Formula C10H24ClNO4S
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Color Colorless to light yellow
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SMILES
SCCOCCOCCOCCOCCN.Cl
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Synonyms
SH-PEG4-NH2 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 125 mg/mL (431.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4504 mL | 17.2521 mL | 34.5042 mL | 86.2604 mL |
| 5 mM | 0.6901 mL | 3.4504 mL | 6.9008 mL | 17.2521 mL | |
| 10 mM | 0.3450 mL | 1.7252 mL | 3.4504 mL | 8.6260 mL | |
| 15 mM | 0.2300 mL | 1.1501 mL | 2.3003 mL | 5.7507 mL | |
| 20 mM | 0.1725 mL | 0.8626 mL | 1.7252 mL | 4.3130 mL | |
| 25 mM | 0.1380 mL | 0.6901 mL | 1.3802 mL | 3.4504 mL | |
| 30 mM | 0.1150 mL | 0.5751 mL | 1.1501 mL | 2.8753 mL | |
| 40 mM | 0.0863 mL | 0.4313 mL | 0.8626 mL | 2.1565 mL | |
| 50 mM | 0.0690 mL | 0.3450 mL | 0.6901 mL | 1.7252 mL | |
| 60 mM | 0.0575 mL | 0.2875 mL | 0.5751 mL | 1.4377 mL | |
| 80 mM | 0.0431 mL | 0.2157 mL | 0.4313 mL | 1.0783 mL | |
| 100 mM | 0.0345 mL | 0.1725 mL | 0.3450 mL | 0.8626 mL |
Thiol-PEG4-NH2 hydrochloride Related Classifications
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