2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid

Name: 2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid
Brand: MedChemExpress
SKU: HY-43048
Rating: 4.5 (1 reviews)

Cat. No.: HY-43048 Pureza: 95.0%: Ficha de datos
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2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid is a PROTACT linker in PROTAC SMARCA2/4-degrader-34 (HY-169279).

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2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid Estructura química

No. CAS : 2231744-57-1

Tamaño	Stock	Cantidad
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	En stock	Estimated Time of Arrival: December 31
1 g	En stock	Estimated Time of Arrival: December 31
5 g	Obtener un presupuesto
10 g	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid is a PROTACT linker in PROTAC SMARCA2/4-degrader-34 (HY-169279)^[1].

Peso molecular

238.71

Fòrmula

C₁₀H₁₉ClO₄

No. CAS

2231744-57-1

Appearance

Liquid

Color

Colorless to light yellow

SMILES

ClCCCCCCOCCOCC(O)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (418.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1892 mL	20.9459 mL	41.8918 mL
5 mM	0.8378 mL	4.1892 mL	8.3784 mL
10 mM	0.4189 mL	2.0946 mL	4.1892 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.47 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.47 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (10.47 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureza y Documentación

Purity: 95.0%

Select Batch:

Ficha de datos (266 KB) SDS (393 KB)

COA (240 KB) HNMR (275 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Andrew D Huber, et al. First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy. J Med Chem. 2024 Oct 24;67(20):18549-18575. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1892 mL	20.9459 mL	41.8918 mL	104.7296 mL
	5 mM	0.8378 mL	4.1892 mL	8.3784 mL	20.9459 mL
	10 mM	0.4189 mL	2.0946 mL	4.1892 mL	10.4730 mL
	15 mM	0.2793 mL	1.3964 mL	2.7928 mL	6.9820 mL
	20 mM	0.2095 mL	1.0473 mL	2.0946 mL	5.2365 mL
	25 mM	0.1676 mL	0.8378 mL	1.6757 mL	4.1892 mL
	30 mM	0.1396 mL	0.6982 mL	1.3964 mL	3.4910 mL
	40 mM	0.1047 mL	0.5236 mL	1.0473 mL	2.6182 mL
	50 mM	0.0838 mL	0.4189 mL	0.8378 mL	2.0946 mL
	60 mM	0.0698 mL	0.3491 mL	0.6982 mL	1.7455 mL
	80 mM	0.0524 mL	0.2618 mL	0.5236 mL	1.3091 mL
	100 mM	0.0419 mL	0.2095 mL	0.4189 mL	1.0473 mL