Asialoglycoprotein Receptor (ASGPR) Ligand
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Trivalent GalNAc-DBCO
0 ImagesCat. No.: HY-160291CAS No.: 2765060-22-6Trivalent GalNAc-DBCO is a bifunctional bioconjugation reagent. The trivalent GalNAc cluster binds to ASGPR with high affinity. Trivalent GalNAc-DBCO can be used for oligonucleotide conjugation.
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Mal-C2-amide-C10-tri-GalNAc
0 ImagesMal-C2-amide-C10-tri-GalNAc is an asialoglycoprotein receptor (ASGPR) binding ligand fragment and a component of lysosome-targeted bifunctional molecules. Mal-C2-amide-C10-tri-GalNAc is used in the research of autoimmune diseases.
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tri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-{Arg(3F-Ph)-PEG2}-LGELVWCT) (Cys2-Cys12)
0 Imagestri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-{Arg(3F-Ph)-PEG2}-LGELVWCT) (Cys2-Cys12) is an asialoglycoprotein receptor (ASGPR) ligand that can be used for LYsosome TArgeting Chimera (LYTAC) research.
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PEG9MA10-PAB10-GalMA10
0 ImagesCat. No.: HY-184926PEG9MA10-PAB10-GalMA10 is a CD147 LYTAC degrader. PEG9MA10-PAB10-GalMA10 binds to the asialoglycoprotein receptor (ASGPR) via its galactose methacrylate domain, mediating its uptake by hepatoma cells. PEG9MA10-PAB10-GalMA10 induces lysosome-dependent degradation of CD147, resulting in concurrent loss of associated MCT1 and MCT4. PEG9MA10-PAB10-GalMA10 reduces extracellular lactate levels, increases intracellular lactate accumulation, inhibits glycolytic activity, and enhances mitochondrial respiratory capacity. PEG9MA10-PAB10-GalMA10 decreases the secretion of MMP-2 and MMP-9, and upregulates the expression of E-cadherin. PEG9MA10-PAB10-GalMA10 exhibits anti-tumor efficacy in hepatoma models. PEG9MA10-PAB10-GalMA10 can be used for research on liver cancer (hepatocellular carcinoma).
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TMU454
0 ImagesCat. No.: HY-180909TMU454 is a prototype GalNAc-PROTAC conjugate. TMU454 binds to ASGPR on the membrane of cells, and then is internalized via ASGPR-mediated endocytosis. TMU454 selectively degrades BRD4. TMU454 exhibits anticancer activity against hepatocellular carcinoma.
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ASGPR ligand-1
0 ImagesCat. No.: HY-156994CAS No.: 1426160-58-8ASGPR ligand-1 (Compound int-CC2) is an asialoglycoprotein receptor (ASGPR) ligand with a binding Kd value of 0.9 nM. ASGPR ligand-1 is applicable to research on lysosome degradation-related diseases.
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tri-GalNAc-phosphoric acid
0 ImagesCat. No.: HY-185590CAS No.: 3084453-02-8tri-GalNAc-phosphoric acid is a specific ligand of ASGPR with cell-specific internalization capability. tri-GalNAc-phosphoric acid can mediate the delivery of conjugated sclerostin aptamers to lysosomes of cells expressing ASGPR. tri-GalNAc-phosphoric acid is applicable to anticancer research.
