Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (1003):

By Effects:	Inhibitors (2) Controls (2) Substrate (1) Modulator (1) Chemicals (8) Inducer (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W440888

DSPE-PEG2000-Folate
DSPE-PEG2000-Folate (DSPE-PEG2000 Folate) is a folate-containing PEG derivative. DSPE-PEG2000-Folate possesses targeting activity and binds to folate receptors in cancer cells. DSPE-PEG2000-Folate can be post-inserted into preformed liposomal bilayers to prepare folate-targeted liposomal formulations. DSPE-PEG2000-Folate forms micelles/lipid bilayers and can be used in studies of targeted drug delivery systems[2].

HY-171306

MK16		99.86%
MK16 is a lipid material that can be used to construct blood-brain barrier penetrable lipid nanoparticles for mRNA delivery. MK16 facilitates blood-brain barrier crossing via γ-secretase-mediated and caveolae-mediated transcytosis. MK16 can be used for drug delivery research.

HY-22274

DMPG sodium		99.51%
DMPG sodium is a biochemical reagent. DMPG sodium is used as a liposome carrier to load 6-shogaol (HY-14616) with anticancer activity.

HY-143203

18:0-18:2 PE		98.0%
18:0-18:2 PE is an important component of phosphatidylethanolamine (PE), involved in phospholipid metabolism and associated with diseases such as ovarian cancer. 18:0-18:2 PE in the hot processing process, its unsaturated fatty acids will degrade to form a variety of odor active compounds. 18:0-18:2 PE is mainly used in the field of food science to improve the flavor of aquatic products, as well as medical research on diseases related to phospholipid metabolism.

HY-112757

DLinDMA		99.49%
DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery.

HY-150229

306-N16B		99.27%
306-N16B is a selective lung-targeted lipid nanoparticle that reversibly targets lung endothelial cells and specific immune cells through selective adsorption of a protein corona mediated by differences in tail structure (such as fibrinogen β/γ chain). 306-N16B binds to specific plasma proteins in the blood to form a protein corona, which guides the particles to be enriched in the lungs, releases mRNA and promotes target cell gene expression, exerts efficient lung cell transfection activity, and can precisely regulate gene delivery of different cell types in the lungs (such as endothelial cells and macrophages). 306-N16B can be used in gene therapy technologies for hereditary lung diseases including pulmonary lymphangioleiomyomatosis (LAM), restoring tumor suppressor function by delivering Tsc2 mRNA, and can also be used for lung-specific mRNA vaccines and gene editing therapies.

HY-170706

DSPE-PEG2000-COOH		99.95%
DSPE-PEG (2000)-COOH is a pegylated derivative of 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (HY-112530). DSPE-PEG2000-COOH can form micelles for targeted drug delivery.

HY-151705

Alkyne Cholesterol
Alkyne Cholesterol, a modified lipid, is a click chemistry reagent containing an alkyne group. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents in the presence of a copper (Cu)-containing catalyst. Alkyne Cholesterol can be used for tracking cellular cholesterol metabolism and localization.

HY-133971

Cholesterol 5α,6α-epoxide		98.40%
Cholesterol-5α,6α-epoxide is an epoxide derivative of cholesterol formed by the enzymatic oxidation of cholesterol in the liver and other tissues. Cholesterol-5α,6α-epoxide has unique chemical properties that make it an important intermediate in the biosynthesis of bile acids, which play a key role in the digestion and absorption of dietary fats. It also has a potential physiological role in regulating cholesterol metabolism and transport, although its biological function is not fully understood.

HY-W714524

1-Palmitoyl-2-oleoyl-sn-glycero-3-PS sodium		99.13%
2-Oleoyl-1-palmitoyl-sn-glycero-3-phospho-L-serine sodium (16:0-18:1 PS (POPS)) is an anionic phospholipid with oleic acid (18:1) and palmitic acid (16:0) tails containing a carboxylic acid (COOH) and amine (NH2) in their head group. 2-Oleoyl-1-palmitoyl-sn-glycero-3-phospho-L-serine sodium has been used in the preparation of lipid-mixing vesicles, liposomes, and artificial membranes.

HY-156197

Biotin-cholesterol
Biotin-cholesterol is a biotinylated form of Cholesterol (HY-N0322). Biotin-cholesterol can be used in the synthesis of biotin-conjugated liposomes and micelles for drug delivery.

HY-153378

Lipid 15		98.0%
Lipid 15 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).

HY-141892A

DSPE-PEG2000 Carboxylic acid sodium		98.0%
DSPE-PEG2000 Carboxylic acid sodium is a PEG-lipid that can be used in the preparation of drug delivery nanoparticles.

HY-151226

Glyceryl monostearate		98.0%
Glyceryl monostearate (GMS) is a type of monoglyceride. Glyceryl monostearateGlyceryl monostearate can serve as a core lipid material for constructing solid lipid nanoparticles in the field of drug delivery. Glyceryl monostearate can be used as a gelling agent to structure liquid vegetable oils into semi-solid oleogels, so as to replace animal fat in meat products.

HY-W440719

Cholesterol-PEG2000-MAL
Cholesterol-PEG2000-MAL is a PEG derivative and can be used to prepare liposome or nanoparticle due to its ability to self-assemble in water. The maleimide moiety is reactive with thiol molecule to form a covalent thioether bond.

HY-141629

N-Palmitoyl-D-sphingomyelin		99.90%
N-palmitoyl-D-sphingomyelin (sphingomyelin 16:0) is a component of LDL-carrying liposomes. N-palmitoyl-D-sphingomyelin can be used in colorectal cancer research.

HY-W590681

113-O12B		99.79%
113-O12B is a disulfide bond-containing ionizable cationic lipidoid. 113-O12B can be used in that generation of lipid nanoparticles (LNPs) for the delivery of mRNA.

HY-W130610

Stearamide
Stearamide is a primary fatty acid amide. Stearamide displays cytotoxic and ichthytoxic activity.

HY-145742

1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium		98.0%
1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is the component of liposomes for drug delivery.

HY-115415

1,2-Distearoyl-sn-glycero-3-phosphate sodium		98.0%
1,2-Distearoyl-sn-glycero-3-phosphate, sodium salt is a phospholipid commonly used as a component of liposome formulations and drug delivery systems. 1,2-Distearoyl-sn-glycero-3-phosphate, sodium salt has unique chemical properties that make it an effective tool for encapsulating drugs and delivering them to specific targets in the body. It acts as a stabilizer and emulsifier, which can improve the solubility and bioavailability of drugs.

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