321863-21-2
Chemical Structure
1-Palmitoyl-2-oleoyl-sn-glycero-3-PS sodium
Synonym(s): 16:0-18:1 PS (POPS)
- CAS No.: 321863-21-2
- Formula:C40H75NNaO10P
- Molecular Weight:783.99
InChIKey: RQYKXRYGZHMUSU-JEAFVVATSA-M
SMILES: OC([C@@H](N)COP(OC[C@@H](COC(CCCCCCCCCCCCCCC)=O)OC(CCCCCCC/C=C\CCCCCCCC)=O)(O[Na])=O)=O
Biological Activity: 1-Palmitoyl-2-oleoyl-sn-glycero-3-PS sodium (16:0-18:1 PS (POPS)) is an anionic phosphatidylserine phospholipid with 16:0 (palmitoyl) and 18:1 (oleoyl) acyl chains. It serves as a component of biomimetic inner plasma membrane models and membrane vesicles for hemostatic response studies. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PS sodium regulates membrane electrical properties by forming tethered bilayer lipid membranes. It enhances the stability of sHDL particles without altering the cholesterol efflux capacity of sHDL. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PS sodium acts synergistically with phosphatidylcholine to support prothrombin activation. It serves as a component of the 4:1 POPC/POPS binary lipid bilayer model. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PS sodium is applicable to research related to atherosclerosis[1][2][3][4].
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PS sodium | 99.84% | 1-Palmitoyl-2-oleoyl-sn-glycero-3-PS sodium (16:0-18:1 PS (POPS)) is an anionic phosphatidylserine phospholipid with 16:0 (palmitoyl) and 18:1 (oleoyl) acyl chains. It serves as a component of biomimetic inner plasma membrane models and membrane vesicles for hemostatic response studies. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PS sodium regulates membrane electrical properties by forming tethered bilayer lipid membranes. It enhances the stability of sHDL particles without altering the cholesterol efflux capacity of sHDL. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PS sodium acts synergistically with phosphatidylcholine to support prothrombin activation. It serves as a component of the 4:1 POPC/POPS binary lipid bilayer model. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PS sodium is applicable to research related to atherosclerosis. | ||||||||||||||||||||
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1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine-d3 ammonium | 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine-d3 (1,2-POPS-d3) ammonium is the deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine ammonium. | |||||||||||||||||||||
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1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine-d62 ammonium | 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine-d62 ammonium (1,2-POPS-d62 ammonium) is the deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine ammonium. | |||||||||||||||||||||
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References
- [1]. Silin VI, et al. pH dependent electrical properties of the inner- and outer- leaflets of biomimetic cell membranes. Journal of colloid and interface science. 2021 Jul 15;594:279-289. [Content Brief]
- [2]. Yu M, et al. Enhancement of Anti-inflammatory Effects of Synthetic High-Density Lipoproteins by Incorporation of Anionic Lipids. Molecular pharmaceutics. 2023 Nov 06;20(11):5454-5462. [Content Brief]
- [3]. Banerjee, et al. In-Silico-Mutation-and-Binding-Studies-of-Human In Silico Mutation and Binding Studies of Human FVIIa γ‑Carboxyglutamic Acid-Domain to Endothelial Protein C Receptor: A Molecular Dynamics Simulation Approach[J]. ACS Omega, 2019, 4(1): 496-508.
- [4]. Smirnov MDC, et al. The effect of membrane composition on the hemostatic balance. Biochemistry. 1999 Mar 23;38(12):3591-8. [Content Brief]
