Liposome
Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.
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Liposome Related Products (1265)
Related Products (1265)
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18:1-12:0 Biotin PC
0 ImagesCat. No.: HY-N15984CAS No.: 2260669-99-418:1-12:0 Biotin PC can be used in lipid blot analysis for studying the interactions of Niemann-Pick C2 (NPC2)-lipid. 18:1-12:0 Biotin PC is also used to prepare liposomes.
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (Standard)
0 ImagesCat. No.: HY-W583868RCAS No.: 26662-94-2Synonyms: 1,2-POPE (Standard); 16:0-18:1 PE (Standard)1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (Standard) (1,2-POPE (Standard)) is the analytical standard of 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (HY-W583868). This product is intended for research and analytical applications. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines.
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18:1 PE-PEG2000-Benzylguanine ammonium
0 ImagesCat. No.: HY-N15896CAS No.: 2389168-47-018:1 PE-PEG2000-Benzylguanine ammonium is a SNAP-tag reacting lipid.
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3,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol]
![3,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol]](https://file.medchemexpress.com/product_pic/hy-w800848.gif "Click to View 3,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol] Product Detail")
0 ImagesCat. No.: HY-W800848CAS No.: 1436860-67-13,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol] is a SS-cleavable proton-activated lipid-like material (SSPalm). 3,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol] can be used for delivery of plasmid DNA.
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N-Methyldioctadecylamine
0 ImagesCat. No.: HY-W327840CAS No.: 4088-22-6Synonyms: Dioctadecylmethylamine; MDOAN-Methyldioctadecylamine (Dioctadecylmethylamine; MDOA) is a surfactant and an ionizable cationic helper lipid that can be used for the preparation of lipid nanoparticles. When used in combination with iPhos 9A1P9 (HY-W590683) in ionizable lipid nanoparticles (iPLNPs), N-Methyldioctadecylamine enables liver-selective mRNA expression. N-Methyldioctadecylamine supports initial in vitro and in vivo mRNA delivery screening for iPhos lipids.
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CP-LC-1073
0 ImagesCat. No.: HY-W1130407CAS No.: 3112948-09-8Synonyms: VC-LC-1073CP-LC-1073 is a specific ionizable cationic amino lipid derived from the amino acid homocysteine. CP-LC-1073 can used in lipid nanoparticle (LNP) formulations for efficient in vivo delivery and expression of RNA (mRNA, cRNA, saRNA).
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18:1 Biotinyl PE
0 ImagesCat. No.: HY-W800796CAS No.: 384835-53-4Synonyms: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(biotinyl)18:1 Biotinyl PE is a biotin-functionalized lipid attached to a phosphoethanolamine linked to two oleic acid groups.
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DSPE-PEG5000-Biotin
0 ImagesCat. No.: HY-140736BCAS No.: 385437-57-0DSPE-PEG5000-Biotin is a biotin-labeled PEG derivative composed of phospholipid (DSPE), a hydrophilic polyethylene glycol chain (PEG5000) and a biotin tag. DSPE-PEG5000-Biotin is widely used in scientific research for constructing targeted liposomes, micelles and lipid nanoparticles for drug delivery and cell binding experiments.
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DSPE-alkyne
0 ImagesCat. No.: HY-W440998CAS No.: 2933227-70-2DSPE-alkyne is a phospholipid. DSPE-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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CP-LC-0743
0 ImagesCat. No.: HY-172014CAS No.: 3040858-73-6CP-LC-0743 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA).
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DSPE-PEG5000-Rhodamine
0 ImagesCat. No.: HY-W440921DSPE-PEG5000-Rhodamine is a phospholipid polyPEG with red fluorescent. The polymer can form lipid bilayer and be used to prepare nanoparticles or liposomes for targeted drug delivery. Rhodamine has maximum absorption at 570 nm and emission around 595 nm and can be easily traced using an imaging technique.
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6,6′-Trehalose dioleate
0 ImagesCat. No.: HY-W1121519CAS No.: 338733-40-76,6′-Trehalose dioleate is a glycolipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
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Witepsol
0 ImagesCat. No.: HY-145782CAS No.: 91744-42-2Witepsol is a selective lipid-based vehicle for use in drug delivery systems.
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ALC-0159 (GMP)
0 ImagesCat. No.: HY-138300GCAS No.: 1849616-42-7ALC-0159 (GMP) is the GMP-grade form of ALC-0159 (HY-138300). GMP-grade small molecules can serve as auxiliary reagents in cell therapy. ALC-0159 is a pegylated lipid that acts as a component of mRNA lipid nanoparticles (LNPs). ALC-0159 presents highly mobile surface PEG chains in a dense brush-like conformation, which can form a hydrophilic barrier, reduce non-specific protein adsorption and macrophage uptake, improve colloidal stability, prolong in vivo circulation time, and affect the cellular uptake of LNPs. ALC-0159 dissociates from the surface of mRNA-LNPs under long-term mechanical oscillation stress, thereby reducing steric hindrance, inducing mRNA-LNP fusion, increasing particle size, and releasing unencapsulated mRNA.
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Dioctadecylamine
0 ImagesDioctadecylamine (DODA) is a secondary amine that has been shown to self-organize in plate-like structures in aqueous solution. Dioctadecylamine exhibits sufficiently hydrophobic properties of nanoparticles and good dispersibility in nonpolar solvent. Dioctadecylamine does not form a monolayer above pH 3.9.
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ALC-0315 (GMP Like)
0 ImagesALC-0315 (GMP Like) is ALC-0315 (HY-138170) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.
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Stearic acid-PEG2000-FITC
0 ImagesCat. No.: HY-W440938Stearic acid-PEG2000-FITC is an amphiphatic polyPEG which can self assemble to form micelles in water. The polymer can be used to encapsulate therapeutic agent. FITC is a green dye with peak absorption at 494 nm and maximum emission at 520 nm and can be used for staining biological samples or nanoparticles. FITC can be easily traced by fluorescence microscopy.
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-13C16
0 ImagesCat. No.: HY-130462S2CAS No.: 2692624-41-0Synonyms: POPC-13C161-Palmitoyl-2-oleoyl-sn-glycero-3-PC-13C16 (POPC-13C16) is 13C labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers.
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DMPE-PEG1000 ammonium
0 ImagesCat. No.: HY-155927CAS No.: 474922-82-2Synonyms: 14:0 PEG1000 PE ammonium; 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-1000] ammoniumDMPE-PEG1000 ammonium (14:0 PEG1000 PE ammonium) is a methoxy-capped PEGylated phospholipid containing two C14 lipid chains and a PEG1000 group. DMPE-PEG1000 can be incorporated as a PEG-lipid component into conjugated polymer nanoparticles for nanoparticle surface modification. DMPE-PEG1000 ammonium is applicable for researches related to PEGylated nanoparticle preparation and fluorescence imaging.
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PS
0 ImagesSynonyms: 16:0-18:1 PS (POPS) free acid2-Oleoyl-1-palmitoyl-sn-glycero-3-phospho-L-serine (16:0-18:1 PS (POPS) free acid) is an anionic phospholipid with oleic acid (18:1) and palmitic acid (16:0) tails containing a carboxylic acid (COOH) and amine (NH2) in their head group. 2-Oleoyl-1-palmitoyl-sn-glycero-3-phospho-L-serine has been used in the preparation of lipid-mixing vesicles, liposomes, and artificial membranes.
