ALC-0159 (GMP)
Based on 1 Customer Validation
ALC-0159 (GMP) is the GMP-grade form of ALC-0159 (HY-138300). GMP-grade small molecules can serve as auxiliary reagents in cell therapy. ALC-0159 is a pegylated lipid that acts as a component of mRNA lipid nanoparticles (LNPs). ALC-0159 presents highly mobile surface PEG chains in a dense brush-like conformation, which can form a hydrophilic barrier, reduce non-specific protein adsorption and macrophage uptake, improve colloidal stability, prolong in vivo circulation time, and affect the cellular uptake of LNPs. ALC-0159 dissociates from the surface of mRNA-LNPs under long-term mechanical oscillation stress, thereby reducing steric hindrance, inducing mRNA-LNP fusion, increasing particle size, and releasing unencapsulated mRNA.
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- No. CAS: 1849616-42-7
- Fòrmula: (C2H4O)nC31H63NO2
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
ALC-0159 (GMP) can serve as a PEG-lipid component for the preparation of mRNA-loaded LNPs and MSC-Hyb NPs derived from extracellular vesicles of human mesenchymal stem cells; such LNPs are capable of delivering COL1A1 mRNA to diseased human tendon stem/progenitor cells (TSPCs)[1].
ALC-0159 (GMP) achieves 90% PEG coating efficiency on intact COMIRNATY mRNA-LNP, and the PEG chains on the LNP surface have high mobility; it forms a dense brush-like PEG conformation on the LNP surface[2].
ALC-0159 (GMP) (under shaking-induced mechanical stress) exhibits decreased PEG signal and mobility on mRNA-LNPs, triggers LNP aggregation and particle size increment, forms large liposome-like structures accompanied by free mRNA release, which indicates the detachment of ALC-0159 from the LNP surface[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1849616-42-7
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Fòrmula (C2H4O)nC31H63NO2
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SMILES
CCCCCCCCCCCCCCN(C(COCCOC)=O)CCCCCCCCCCCCCC.[n]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALC-0159 (GMP) Related Classifications
HY-138300G Related Classifications
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