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Art. -Nr.: HY-138300G

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ALC-0159 (GMP)

Name: ALC-0159 (GMP)
Brand: MedChemExpress
SKU: HY-138300G
Price: 2480.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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ALC-0159 (GMP) is the GMP-grade form of ALC-0159 (HY-138300). GMP-grade small molecules can serve as auxiliary reagents in cell therapy. ALC-0159 is a pegylated lipid that acts as a component of mRNA lipid nanoparticles (LNPs). ALC-0159 presents highly mobile surface PEG chains in a dense brush-like conformation, which can form a hydrophilic barrier, reduce non-specific protein adsorption and macrophage uptake, improve colloidal stability, prolong in vivo circulation time, and affect the cellular uptake of LNPs. ALC-0159 dissociates from the surface of mRNA-LNPs under long-term mechanical oscillation stress, thereby reducing steric hindrance, inducing mRNA-LNP fusion, increasing particle size, and releasing unencapsulated mRNA.

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CAS. Nr.: 1849616-42-7
Formel: (C₂H₄O)nC₃₁H₆₃NO₂

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

ALC-0159 (GMP) Chemical Structure

CAS. Nr.: 1849616-42-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Bioz

Biologische Aktivität

Beschreibung

In Vitro

ALC-0159 (GMP) can serve as a PEG-lipid component for the preparation of mRNA-loaded LNPs and MSC-Hyb NPs derived from extracellular vesicles of human mesenchymal stem cells; such LNPs are capable of delivering COL1A1 mRNA to diseased human tendon stem/progenitor cells (TSPCs)^[1].
ALC-0159 (GMP) achieves 90% PEG coating efficiency on intact COMIRNATY mRNA-LNP, and the PEG chains on the LNP surface have high mobility; it forms a dense brush-like PEG conformation on the LNP surface^[2].
ALC-0159 (GMP) (under shaking-induced mechanical stress) exhibits decreased PEG signal and mobility on mRNA-LNPs, triggers LNP aggregation and particle size increment, forms large liposome-like structures accompanied by free mRNA release, which indicates the detachment of ALC-0159 from the LNP surface^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1849616-42-7
Formel (C₂H₄O)nC₃₁H₆₃NO₂
SMILES

CCCCCCCCCCCCCCN(C(COCCOC)=O)CCCCCCCCCCCCCC.[n]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Pareja Tello R, et al. Hybrid lipid nanoparticles derived from human mesenchymal stem cell extracellular vesicles by microfluidic sonication for collagen I mRNA delivery to human tendon progenitor stem cells. Biomaterials Science, 2025, 13(8):2066-2081.

[2]. Wang MM, et al. Elucidation of lipid nanoparticle surface structure in mRNA vaccines. Scientific reports. 2023 Oct 05;13(1):16744.

[3]. Jensen EL, et al. Elucidating the underlying mechanism of mechanical stress-induced impact on mRNA-LNP structure. Scientific reports. 2025 Oct 30;15(1):38009.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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