ALC-0159 (GMP Like) is the GMP-grade form of ALC-0159 (HY-138300). GMP-grade small molecules can serve as auxiliary reagents in cell therapy. ALC-0159 is a pegylated lipid that acts as a component of mRNA lipid nanoparticles (LNPs). ALC-0159 presents highly mobile surface PEG chains in a dense brush-like conformation, which can form a hydrophilic barrier, reduce non-specific protein adsorption and macrophage uptake, improve colloidal stability, prolong in vivo circulation time, and affect the cellular uptake of LNPs. ALC-0159 dissociates from the surface of mRNA-LNPs under long-term mechanical oscillation stress, thereby reducing steric hindrance, inducing mRNA-LNP fusion, increasing particle size, and releasing unencapsulated mRNA.
For research use only. We do not sell to patients.
- CAS No.: 1849616-42-7
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
Description
In Vitro
ALC-0159 (GMP Like) can serve as a PEG-lipid component for the preparation of mRNA-loaded LNPs and MSC-Hyb NPs derived from extracellular vesicles of human mesenchymal stem cells; such LNPs are capable of delivering COL1A1 mRNA to diseased human tendon stem/progenitor cells (TSPCs)[1].
ALC-0159 (GMP Like) achieves 90% PEG coating efficiency on intact COMIRNATY mRNA‑LNP, and the PEG chains on the LNP surface have high mobility; it forms a dense brush‑like PEG conformation on the LNP surface[2].
ALC-0159 (GMP Like) (under shaking‑induced mechanical stress) exhibits decreased PEG signal and mobility on mRNA‑LNPs, triggers LNP aggregation and particle size increment, forms large liposome‑like structures accompanied by free mRNA release, which indicates the detachment of ALC‑0159 from the LNP surface[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1849616-42-7
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SMILES
CCCCCCCCCCCCCCN(C(COCCOC)=O)CCCCCCCCCCCCCC.[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALC-0159 (GMP Like) Related Classifications
HY-138300GL Related Classifications
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