Liposome
Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.
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Liposome Related Products (1265)
Related Products (1265)
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ALC-0315 (GMP)
0 ImagesCat. No.: HY-138170GCAS No.: 2036272-55-4ALC-0315 (GMP) is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 (GMP) can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.
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a12k4E-Ca
0 ImagesCat. No.: HY-185984a12k4E-Ca is a C-terminal glutamate-modified peptidogenic ionizable lipid that can be used for the preparation of lipid nanoparticles (LNPs). a12k4E-Ca preferentially accumulates in the spleen in vivo, acts as a carrier to mediate spleen-selective mRNA delivery, and enables spleen-specific Cre recombinase-mediated gene editing. a12k4E-Ca restores serum biochemical parameters and cytokines/chemokines. a12k4E-Ca can be used in studies related to LNP preparation.
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Cardiolipin (16:1/16:1/16:1/16:1) sodium salt
0 ImagesCat. No.: HY-157657CAS No.: 2260669-34-7Synonyms: Diphosphatidylglycerol sodium salt; 16:1 Cardiolipin sodium salt; 64:4-CL sodium saltCardiolipin (16:1/16:1/16:1/16:1) (Diphosphatidylglycerol; 16:1 Cardiolipin; 64:4-CL ) sodium salt, phospholipid, is a natural killer T (NKT) cells agonist. Cardiolipin (16:1/16:1/16:1/16:1) sodium salt induces increased cytokine (IL-2) production by NKT cell hybridomas. Cardiolipin (16:1/16:1/16:1/16:1) sodium salt can be used for the researches of cancer and immunology.
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DSPC-d74
0 ImagesSynonyms: 1,2-Distearoyl-sn-glycero-3-PC-d74; 1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d74DSPC-d74 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d74) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
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Heptadecan-9-yl 8-((6-(decyloxy)-6-oxohexyl)(2-hydroxyethyl)amino)octanoate
0 ImagesCat. No.: HY-148363CAS No.: 2714482-26-3
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F-L319
0 ImagesCat. No.: HY-185760F-L319 is an ionizable lipid and spleen-targeting mRNA delivery vector. F-L319 can be formulated into lipid nanoparticles (LNPs) to drive spleen-restricted reporter protein expression in mice. F-L319 modulates mRNA encapsulation efficiency, cellular uptake efficiency, and delivery efficiency, with effects varying depending on the composition of LNP formulations. When prepared as pure LNPs, F-L319 shows poor mRNA delivery efficiency in cells; in contrast, hybrid LNPs containing F-L319 and L319 significantly enhance mRNA delivery efficiency in cells.
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diC8PI(3,5)P2 triammonium
0 ImagesCat. No.: HY-157713CAS No.: 852043-36-8Synonyms: 08:0 PI(3,5)P2 triammoniumdiC8PI(3,5)P2 (08:0 PI(3,5)P2) triammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
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1-1(Z)-Octadecenyl-2-adrenoyl-sn-glycero-3-PC
0 ImagesCat. No.: HY-1751131-1(Z)-Octadecenyl-2-adrenoyl-sn-glycero-3-PC is a plasmalogen that contains 1(Z)-octadecenoic acid and adrenic acid (HY-W013215) at the sn-1 and sn-2 positions, respectively.
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C9-200
0 ImagesCat. No.: HY-172335C9-200 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs). C9-200-based LNPs encapsulating mRNA encoding erythropoietin (EPO) can induced EPO production and stimulate red blood cell production in mice.
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Lipid 11
0 ImagesCat. No.: HY-165427CAS No.: 2758820-82-3Lipid 11 (Compound Lipid 1) is a cationic lipid for nucleic acid delivery. Lipid 11 forms lipid nanoparticles (LNPs) through electrostatic binding with nucleic acids (such as ceDNA). Lipid 11 forms complexes with negatively charged nucleic acids via cationic amine groups, which can be endocytosed by cells to release nucleic acids for activity. Lipid 11 is promising for research of gene therapy drug delivery systems.
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DSPE-PEG2000-tetrazine
0 ImagesCat. No.: HY-183964CAS No.: 3101670-39-4DSPE-PEG2000-tetrazine is a synthetic phospholipid modified with PEG2000 and tetrazine moieties. DSPE-PEG2000-tetrazine gains improved steric stability via PEGylation. DSPE-PEG2000-tetrazine enables bioorthogonal click chemistry through its tetrazine segment, which selectively reacts with trans-cyclooctene (TCO) under complex biological environments. DSPE-PEG2000-tetrazine can be applied for researches related to click chemistry.
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SIL lipid
0 ImagesCat. No.: HY-169484CAS No.: 1566559-79-2SIL lipid is the synthetic ionized lipid, and can be used for synthesis of lipid nanoparticles (LNPs) for siRNA delivery.
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BGTC
0 ImagesCat. No.: HY-142996CAS No.: 182056-06-0BGTC is a non-amino acid cationic lipid. BGTC can be used for delivery of nucleic acids.
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Glyceryl monostearate-d5
0 ImagesCat. No.: HY-W704076CAS No.: 1432065-28-5Synonyms: GMS-d5Glyceryl monostearate-d5 (GMS-d5) is deuterium labeled Glyceryl monostearate. Glyceryl monostearate (GMS) is a single-tailed lipidic monoglyceride that can be used to synthesize nanoliposomes for drug delivery.
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1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine
0 ImagesSynonyms: MPPC; PC(14:0/16:0)1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine (MPPC) is an asymmetrical phosphatidylcholine containing a myristic acid (14:0) at the sn-1 position and a palmitic acid (16:0) at the sn-2 position. It is commonly used in the generation of micelles, liposomes, and other types of artificial membranes.
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LNP Lipid-12
0 ImagesCat. No.: HY-173297CAS No.: 2036272-53-2LNP Lipid-12 can be exploited for creating lipid nanoparticles (LNPs).
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(6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-amine
0 ImagesCat. No.: HY-185831CAS No.: 1226768-75-7(6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-amine is an ionizable cationic lipid compound that forms lipid nanoparticles for nucleic acid delivery.
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THP1 Lipid
0 ImagesCat. No.: HY-171953CAS No.: 3097638-13-3THP1 Lipid is an ionizable lipidoid. THP1 Lipid can be used to synthesize lipid nanoparticles (LNPs) for delivering mRNA to muscles with minimal toxicity and editing genes in specific liver tissues in tdTomato transgenic mice model. THP1 Lipid can be used for vaccine delivery and CRISPR/Cas9-mediated gene editing research.
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1,2-Dioleoyl-3(S)-trimethylammoniumpropane chloride
0 ImagesSynonyms: (S)-DOTAP chloride1,2-Dioleoyl-3(S)-trimethylammoniumpropane chloride is a biochemical reagent.
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18:0-20:4 PI (4,5) P2 triammonium
0 ImagesCat. No.: HY-157643CAS No.: 799268-59-018:0-20:4 PI (4,5) P2 triammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
