1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite

Adrenic Acid (Synonyms: cis-7,10,13,16-Docosatetraenoic acid)

Cat. No.: HY-W013215
Handling Instructions

Adrenic Acid is an inflammation enhancer in non-alcoholic fatty liver disease.

For research use only. We do not sell to patients.

Adrenic Acid Chemical Structure

Adrenic Acid Chemical Structure

CAS No. : 28874-58-0

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Adrenic Acid is an inflammation enhancer in non-alcoholic fatty liver disease.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Adrenic acid is produced via the elongation of arachidonic acid by ELOVL2 and 5. Interestingly, the hepatic level of free Adrenic Acid (22:4n6) is markedly higher in the CDAHFD-fed db/db mice than in the SD-fed db/db mice. In plasma, the difference in the adrenic acid level reaches statistical significance (p<0.001). It is also found that the concentrations of phospholipid species containing Adrenic Acid, such as PC or PE (40:4) (containing side chain 18:0/22:4), and LPC 22:4 (sn-1/sn-2), are also significantly increased. (sn-1/sn-2). The hepatic and plasma levels of Adrenic Acid, which is an omega 6 polyunsaturated fatty acid (PUFA), exhibit greater differences between the CDAHFD-fed db/db mice and the SD-fed db/db mice (8.6-fold higher vs. 1.6-fold higher in liver tissue, 5.3-fold higher vs. 2.2-fold higher in plasma) than those of well-known proinflammatory PUFA, such as Arachidonic Acid[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0072 mL 15.0362 mL 30.0725 mL
5 mM 0.6014 mL 3.0072 mL 6.0145 mL
10 mM 0.3007 mL 1.5036 mL 3.0072 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

332.53

Formula

C₂₂H₃₆O₂

CAS No.

28874-58-0

SMILES

CCCCC/C=C/C/C=C/C/C=C/C/C=C\CCCCCC(O)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Adrenic Acid
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Adrenic Acid

Cat. No.: HY-W013215